ZnAl layered double hydroxides impregnated with eucalyptus oil as efficient hybrid materials against multi-resistant bacteria
ZnAl layered double hydroxides impregnated with eucalyptus oil as efficient hybrid materials against multi-resistant bacteria
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DOI：
10.1016/j.clay.2017.11.017
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发表时间：
2018-03
影响因子：
5.6
通讯作者：
M. Lobo-Sánchez;Gisel Nájera-Meléndez;G. Luna;Verónica Segura-Pérez;J. A. Rivera;G. Fetter
中科院分区：
文献类型：
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作者：
M. Lobo-Sánchez;Gisel Nájera-Meléndez;G. Luna;Verónica Segura-Pérez;J. A. Rivera;G. Fetter
细菌污染对人类健康构成严重危害。使用杀菌材料，如层状双氢氧化物，可能是降低疾病风险的一种方式。本工作在不同pH值和不同金属摩尔比的条件下，利用微波辐射合成了锌铝层状双氢氧化物，并对其进行了抗多重耐药试验。在某些情况下，选择合成条件来形成含锌矿(氧化锌)的复合材料，锌矿和层状双氢氧化物都是众所周知的有效的抗菌剂。桉树油是一种杀菌化合物，从桉树叶中提取并用于浸渍一些层状双氢氧化物-锌矿复合材料。用X射线衍射仪、红外光谱、氮气物理吸附和扫描电子显微镜对材料进行了表征。对样品进行了抗葡萄球菌试验。和铜绿假单胞菌，这是多重耐药细菌。结果表明，层状双氢氧化物合成过程中，锌铝摩尔比、pH和桉油包裹体等因素决定了其杀菌活性。表现最好的样品是那些含有桉树油的样品，桉树油在非常低的浓度下能够杀死葡萄球菌。抑制铜绿假单胞菌生长。
Bacterial contamination poses a serious hazard for human health. The use of bactericidal materials, such as layered double hydroxides, might constitute a way to reduce the risk of diseases. In this work, ZnAl layered double hydroxides were synthesized by microwave irradiation at different pH values and various metal molar ratios to be tested against multi-resistant bacteria. The synthesis conditions were chosen to form, in some cases, a composite containing zincite (ZnO), as both materials, zincite as well as the layered double hydroxide, are well known to be efficient antimicrobials.Eucalyptus extracted oil, which is a bactericidal compound, was extracted from eucalyptus leaves and used to impregnate some layered double hydroxide–zincite composites. The materials were characterized by X-ray diffraction, infrared spectroscopy, nitrogen physisorption and scanning electron microscopy. The samples were tested againstStaphylococcussp. andPseudomonasaeruginosa, which are multi-resistant bacteria. It was found that Zn/Al molar ratio, pH and inclusion of eucalyptus oil in the layered double hydroxides synthesis determined the bactericidal activity. The best performing samples were those containing eucalyptus oil, which, at very low concentrations, were able to killStaphylococcussp. and inhibit thePseudomonas aeruginosagrowth.