Imaging for assessment of radiation-induced normal tissue effects.
Imaging for assessment of radiation-induced normal tissue effects.
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用于评估辐射引起的正常组织影响的成像。
DOI：
10.1016/j.ijrobp.2009.08.077
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发表时间：
2010-03-01
影响因子：
7
通讯作者：
Marks, Lawrence
中科院分区：
文献类型：
--
作者：
Jeraj, Robert;Cao, Yue;Ten Haken, Randall K.;Hahn, Carol;Marks, Lawrence
成像可以提供对辐射引起的正常组织影响的定量评估。通过成像识别正常组织损伤的早期迹象将有可能预测器官功能障碍，从而允许根据个别患者的风险和好处重新优化治疗策略。非侵入性成像的早期检测可能使干预措施能够在临床表现之前减轻与治疗相关的损伤。此外，连续成像可提供此类缓解疗法的影响的客观评估。然而，许多问题使得成像在正常组织评估中的应用具有挑战性，需要进一步的工作来建立成像生物标记物作为临床结果的替代终点。以正常组织损伤为明确终点的临床试验的实施将极大地帮助实现这些目标。
Imaging can provide quantitative assessment of radiation-induced normal tissue effects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ dysfunction, thereby allowing re-optimization of treatment strategies based upon individual patients’ risks and benefits. Early detection with non-invasive imaging may enable interventions to mitigate therapy-associated injury prior to its clinical manifestation. Further, successive imaging may provide an objective assessment of the impact of such mitigation therapies. However, many problems make application of imaging to normal tissue assessment challenging, and further work is required to establish imaging biomarkers as surrogate endpoints of clinical outcome. The performance of clinical trials where normal tissue injury is a clearly defined endpoint would greatly aid in realization of these goals.
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影响因子：
3.8
作者：
Cao, Yue;Platt, Joel F.;Lawrence, Theodore S.
通讯作者：
Lawrence, Theodore S.
影响因子：
51.1
作者：
Darby, SC;McGale, P;Peto, R
通讯作者：
Peto, R
影响因子：
45.3
作者：
Fan, M;Marks, LB;Munley, MT
通讯作者：
Munley, MT
DOI：
10.1016/j.ijrobp.2005.01.029
发表时间：
2005-09-01
影响因子：
7
作者：
Marks, LB;Yu, XL;Borges-Neto, S
通讯作者：
Borges-Neto, S
DOI：
10.1016/j.ijrobp.2007.05.078
发表时间：
2008-01-01
影响因子：
7
作者：
Cao, Yue;Pan, Charlie;Lawrence, Theodore S.
通讯作者：
Lawrence, Theodore S.