Fraction of unsaturated fatty acids in visceral adipose tissue (VAT) is lower in subjects with high total VAT volume – a combined 1H MRS and volumetric MRI study in male subjects
Fraction of unsaturated fatty acids in visceral adipose tissue (VAT) is lower in subjects with high total VAT volume – a combined 1H MRS and volumetric MRI study in male subjects
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DOI：
10.1002/nbm.2849
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发表时间：
2013-02
影响因子：
2.9
通讯作者：
J. Machann;N. Stefan;C. Schabel;E. Schleicher;A. Fritsche;C. Würslin;H. Häring;C. Claussen;F. Schick
中科院分区：
文献类型：
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作者：
J. Machann;N. Stefan;C. Schabel;E. Schleicher;A. Fritsche;C. Würslin;H. Häring;C. Claussen;F. Schick
内脏脂肪组织(VAT)在肥胖和胰岛素抵抗的发病机制中起重要作用。然而，关于甘油三酯中单不饱和脂肪酸(MUFAs)和多不饱和脂肪酸(PUFAs)的含量，人们对增值税的组成知之甚少。除MRI外，还进行了容量选择性MRS检查以定量测定VAT。分析包括来自乙烯基H基团(H-C=C-H)的质子信号，包括来自MUFA+PUFA的质子，以及二烯丙基-H，即亚甲基中断的PUFA。以甲基(−CH_3)共振作为参照物，它是唯一具有一定数目的质子/甘油三酯(n=9)的峰。
Visceral adipose tissue (VAT) is thought to play an important role in the pathogenesis of obesity and insulin resistance. However, little is known about the composition of VAT with regard to the amount of mono‐ (MUFAs) and polyunsaturated fatty acids (PUFAs) in triglycerides. Volume‐selective MRS was performed in addition to MRI for the quantification of VAT. Analysis comprised proton signals from the vinyl‐H group (H–C = C–H), including protons from MUFA + PUFA, and diallylic‐H, i.e. methylene‐interrupted PUFAs. The methyl (−CH3) resonance, which is the only peak with a defined number of protons/triglyceride (n = 9), served as reference.