Fish oil supplementation modifies the genetic potential for blood lipids.
Fish oil supplementation modifies the genetic potential for blood lipids.
复制标题
鱼油补充剂可以改变血脂的遗传潜力。
DOI：
10.1101/2023.09.22.23295987
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ye,Kaixiong
中科院分区：
文献类型：
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作者：
Sun,Yitang;McDonald,Tryggvi;Baur,Abigail;Xu,Huifang;Bateman,NaveenBrahman;Shen,Ye;Li,Changwei;Ye,Kaixiong
背景血脂异常是心血管疾病众所周知的危险因素，已成为世界范围内死亡的主要原因。尽管习惯性摄入鱼油可能通过降低甘油三酯来提供心脏保护作用，但鱼油与血脂失调的遗传易感性之间的相互作用仍然难以捉摸。目的研究补充鱼油是否可以改变总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC)和甘油三酯等四种血脂水平的遗传潜力。方法来自英国生物库的441,985名具有完整遗传和表型数据的参与者被纳入我们的研究。计算不同血统参与者的多基因得分(PGS)。多变量线性回归模型被用来评估与相关危险因素调整的相关性。结果补充鱼油减轻了424,090名欧洲血统参与者对总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平升高的遗传易感性，同时放大了高密度脂蛋白胆固醇水平升高的遗传潜力。使用基于多个全基因组关联研究或替代PGS方法计算的PGS，获得了一致的显著结果。我们还表明，鱼油显著降低了非洲血统参与者对高甘油三酯的遗传易感性。结论补充鱼油降低了总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平升高的遗传易感性，同时增加了高密度脂蛋白胆固醇水平的遗传可能性。这些结果表明，鱼油可能对改变普通人群中升高的血脂水平的全基因组遗传效应有有益的影响。
Background Dyslipidemia is a well-known risk factor for cardiovascular disease, which has been the leading cause of mortality worldwide. Although habitual intake of fish oil has been implicated in offering cardioprotective effects through triglyceride reduction, the interactions of fish oil with the genetic predisposition to dysregulated lipids remain elusive. Objectives We examined whether fish oil supplementation can modify the genetic potential for the circulating levels of four lipids, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. Methods A total of 441,985 participants with complete genetic and phenotypic data from the UK Biobank were included in our study. Polygenic scores (PGS) were calculated in participants of diverse ancestries. Multivariable linear regression models were used to assess associations with adjustment for relevant risk factors. Results Fish oil supplementation mitigated genetic susceptibility to elevated levels of total cholesterol, LDL-C, and triglycerides, while amplifying genetic potential for increased HDL-C among 424,090 participants of European ancestry Pinteraction<0.05. Consistent significant findings were obtained using PGS calculated based on multiple genome-wide association studies or alternative PGS methods. We also showed that fish oil significantly attenuated genetic predisposition to high triglycerides in African-ancestry participants. Conclusions Fish oil supplementation attenuated the genetic susceptibility to elevated blood levels of total cholesterol, LDL-C, and triglycerides, while accentuating genetic potential for higher HDL-C. These results suggest that fish oil may have a beneficial impact on modifying genome-wide genetic effects on elevated lipid levels in the general population.