Patient-specific online dose verification based on transmission detector measurements
Patient-specific online dose verification based on transmission detector measurements
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DOI：
10.1016/j.radonc.2016.04.003
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发表时间：
2016-05-01
影响因子：
5.7
通讯作者：
Wertz, Hansjoerg
中科院分区：
文献类型：
--
作者：
Thoelking, Johannes;Fleckenstein, Jens;Wertz, Hansjoerg
背景和目的：由于调强放射治疗技术带来了越来越复杂的环境，建议进行患者特有的调强放射治疗计划验证。此外，在患者照射和3D剂量重建期间进行验证有可能改善治疗的交付、准确性和安全性。本研究对新型传输探测器(DTD)Dolphin(德国IBA剂量学)进行了详细的研究。材料和方法：通过对18个IMRT序列进行二维和三维剂量学计划验证来测试DTD的临床性能。在2D中，通过伽玛指数和剂量差评估将DTD测量与治疗前验证方法和治疗计划系统进行比较。在3D中，评估剂量体积直方图(DVH)指数和伽马分析。此外，在叶片位置不确定和直线加速器(LINAC)输出偏差的情况下测试了错误检测能力。结果：DTD测量结果与二维参考值符合良好(伽马(3%，3 mm)=(99.7+/-0.6)%
Background and purpose: Since IMRT-techniques lead to an increasingly complicated environment, a patient specific IMRT-plan verification is recommended. Furthermore, verifications during patient irradiation and 3D dose reconstruction have the potential to improve treatment delivery, accuracy and safety. This study provides a detailed investigation of the new transmission detector (DTD) Dolphin (IBA Dosimetry, Germany) for online dosimetry.Materials and methods: The clinical performance of the DTD was tested by dosimetric plan verification in 2D and 3D for 18 IMRT-sequences. In 2D, DTD measurements were compared to a pre-treatment verification method and a treatment planning system by gamma index and dose difference evaluations. In 3D, dose volume-histogram (DVH) indices and gamma analysis were evaluated. Furthermore, the error detection ability was tested with leaf position uncertainties and deviations in the linear accelerator (LINAC) output. Results: The DTD measurements were in excellent agreement to reference measurements in both 2D (gamma(3%,3mm) = (99.7 +/- 0.6)%