Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study
Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study
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DOI：
10.3945/ajcn.110.009357
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发表时间：
2011-08-01
影响因子：
7.1
通讯作者：
Pereira, Mark A.
中科院分区：
文献类型：
--
作者：
Brostow, Diana P.;Odegaard, Andrew O.;Pereira, Mark A.
背景资料：ω-3（n-3）脂肪酸（FA）在2型糖尿病发展中的作用尚不确定，尤其是α-亚麻酸（ALA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的差异影响。目的：其目的是研究总omega-3脂肪酸，海洋omega-3脂肪酸，（EPA，DHA）、非海洋omega-3（ALA）和omega-6（n-6）FA以及omega-6：omega-3比例与新加坡中国人群患2型糖尿病的风险。设计：该分析包括新加坡华人健康研究中的43，176名年龄在45-74岁的无慢性病的华人男性和女性。1993年至1998年期间收集了基线数据，1999年至2004年期间进行了后续访谈。考克斯回归模型被用来检查脂肪酸摄入量在基线和发展diabetes.Results的风险之间的关联：总的ω-3脂肪酸的摄入量增加与糖尿病发病率呈负相关[风险比（HR）的第五个相比，第一个五分位数：0.78; 95%CI：0.65，0.94;趋势P = 0.02]。来自海洋来源的欧米茄-3脂肪酸与糖尿病风险无关，而非海洋欧米茄-3脂肪酸摄入量与糖尿病风险密切相关（第五个五分位数与第一个五分位数相比的HR：0.79; 95%CI：0.67，0.93;趋势P = 0.004）。Omega-6和Omega-6：结论：非海洋来源（ALA）的omega-3脂肪酸摄入量与新加坡华人2型糖尿病发病风险降低相关。美国临床营养杂志2011;94：520-6.
Background: The role of omega-3 (n-3) fatty acids (FAs) in the development of type 2 diabetes is uncertain, especially with regard to any differential influence of alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).Objective: The objective was to examine the association between total omega-3 FAs, marine omega-3 (EPA, DHA), nonmarine omega-3 (ALA), and omega-6 (n-6) FAs and omega-6: omega-3 ratio and risk of type 2 diabetes in a Chinese population in Singapore.Design: The analysis included 43,176 Chinese men and women free of chronic disease, aged 45-74 y, in the Singapore Chinese Health Study. Baseline data collection occurred between 1993 and 1998, with follow-up interviews between 1999 and 2004. Cox regression models were used to examine the associations between FA intakes at baseline and risk of developing diabetes.Results: Increased intakes of total omega-3 FAs were inversely associated with diabetes incidence [hazard ratio (HR) for the fifth compared with the first quintile: 0.78; 95% CI: 0.65, 0.94; P for trend = 0.02]. Omega-3 FAs from marine sources were not associated with diabetes risk, whereas nonmarine omega-3 FA intake was strongly associated (HR for the fifth compared with the first quintile: 0.79; 95% CI: 0.67, 0.93; P for trend = 0.004). Omega-6 and omega-6: omega-3 ratio were not associated with incidence of type 2 diabetes.Conclusion: Consumption of nonmarine sources (ALA) of omega-3 FAs is associated with a decreased risk of type 2 diabetes in Chinese Singaporeans. Am J Clin Nutr 2011;94:520-6.