Gold-catalyzed sequential alkyne activation: one-pot synthesis of NH-carbazoles via cascade hydroarylation of alkyne/6-endo-dig carbocyclization reactions.
Gold-catalyzed sequential alkyne activation: one-pot synthesis of NH-carbazoles via cascade hydroarylation of alkyne/6-endo-dig carbocyclization reactions.
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DOI：
10.1021/jo400799b
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发表时间：
2013-06
期刊：
影响因子：
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通讯作者：
Srinivas Samala;A. K. Mandadapu;M. Saifuddin;B. Kundu
中科院分区：
文献类型：
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作者：
Srinivas Samala;A. K. Mandadapu;M. Saifuddin;B. Kundu
报道了一种简单有效的一锅法合成NH-咔唑的方法。该策略包括在Au-Ag组合催化剂的存在下用芳基乙炔处理2-炔基吲哚的一锅反应。该策略的显着特点涉及顺序激活的末端和内部的炔，导致级联的末端炔的氢芳基化和6-内切碳环化反应。该方法的通用性已通过使用一系列2-炔基吲哚和芳基乙炔得到证明。
A simple and efficient one-pot protocol for the synthesis of NH-carbazoles has been described. The strategy comprises a one-pot reaction involving the treatment of 2-alkynyl indoles with arylacetylenes in the presence of an Au-Ag combination catalyst. The salient feature of the strategy involves sequential activation of terminal and internal alkynes leading to the cascade hydroarylation of terminal alkynes and 6-endo-dig carbocyclization reactions. The generality of the method has been demonstrated by using a series of 2-alkynyl indoles and arylacetylenes.