Histamine and motivation.
Histamine and motivation.
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DOI：
10.3389/fnsys.2012.00051
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发表时间：
2012
影响因子：
3
通讯作者：
Valdes JL
中科院分区：
文献类型：
--
作者：
Torrealba F;Riveros ME;Contreras M;Valdes JL
脑组织胺可以影响各种不同的行为和生理功能;然而，它在促进觉醒方面的作用已经超过了它的其他重要功能。在这里，我们回顾证据表明，大脑组胺起着核心作用的动机，并强调其差异参与的食欲和完善阶段的动机行为。我们讨论的输入，控制组胺能神经元的结节乳头状核（TMN）的下丘脑，这决定了这些神经元在食欲行为，睡眠/觉醒周期，和食物的预期反应的独特作用。此外，我们回顾证据支持组胺能神经元和组胺的皮质输入功能障碍，在调节特定形式的动机下降（冷漠）。此外，我们讨论了组胺系统和药物成瘾的动机的背景下之间的关系。
Brain histamine may affect a variety of different behavioral and physiological functions; however, its role in promoting wakefulness has overshadowed its other important functions. Here, we review evidence indicating that brain histamine plays a central role in motivation and emphasize its differential involvement in the appetitive and consummatory phases of motivated behaviors. We discuss the inputs that control histaminergic neurons of the tuberomamillary nucleus (TMN) of the hypothalamus, which determine the distinct role of these neurons in appetitive behavior, sleep/wake cycles, and food anticipatory responses. Moreover, we review evidence supporting the dysfunction of histaminergic neurons and the cortical input of histamine in regulating specific forms of decreased motivation (apathy). In addition, we discuss the relationship between the histamine system and drug addiction in the context of motivation.