The cognitive profile of posterior cortical atrophy
The cognitive profile of posterior cortical atrophy
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DOI：
10.1212/01.wnl.0000196477.78548.db
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发表时间：
2006-02-14
期刊：
影响因子：
9.9
通讯作者：
Kertesz, A
中科院分区：
文献类型：
--
作者：
McMonagle, P;Deering, F;Kertesz, A
背景资料：后皮质萎缩（PCA）是一种进行性痴呆，其特征在于高级视觉处理的显著障碍，影响背侧和腹侧流，导致Balint综合征、失读症和视觉失认症。目的：明确PCA的认知特征，并与典型的原发性遗忘型痴呆（DAT）进行比较。研究方法：作者使用了标准的认知测试和一种新的电池，旨在反映腹侧（物体，面部和颜色失认屏幕[OFCAS]）和背侧（复杂图片和复合刺激）视觉流的功能障碍。作者确定了19名PCA患者，并将其表现与DAT患者和正常对照组进行了比较。结果如下：PCA患者较年轻，在视觉空间任务、阅读和书写方面有明显损伤，但与DAT相比，使用标准测试时记忆相对保留。在PCA患者中，背流征最普遍，没有发现纯粹的腹流综合征。所有新型测试都可靠地区分了具有复杂图片描述和复合刺激处理的受试者，与DAT相比显示出最显着的差异。结论：PCA主要是一种背流综合征，与典型的DAT不同，随着时间的推移，它涉及枕颞区。
Background: Posterior cortical atrophy (PCA) is a progressive dementia characterized by prominent disorders of higher visual processing, affecting both dorsal and ventral streams to cause Balint's syndrome, alexia, and visual agnosia. Objective: To define the cognitive profile of PCA and compare to the typical, primary amnestic dementia of the Alzheimer's type (DAT). Methods: The authors used standard cognitive tests and a novel battery designed to reflect dysfunction in both ventral (Object, Face & Color Agnosia Screen [OFCAS]) and dorsal ( complex pictures and compound stimuli) visual streams. The authors identified 19 patients with PCA and compared their performance to a matched group of patients with DAT and normal controls. Results: Patients with PCA were younger with marked impairment in visuospatial tasks, reading, and writing but relative preservation of memory compared to DAT using standard tests. Dorsal stream signs were most prevalent among the patients with PCA with no pure ventral stream syndromes found. All novel tests distinguished reliably between subjects with complex picture descriptions and processing of compound stimuli showing the most significant differences compared to DAT. Conclusions: PCA is predominantly a dorsal stream syndrome, distinct from typical DAT, which involves occipitotemporal regions over time.