Eleven faces of coronavirus disease 2019
Eleven faces of coronavirus disease 2019
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DOI：
10.1111/all.14289
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发表时间：
2020-04-06
期刊：
影响因子：
12.4
通讯作者：
Gao, Ya-dong
中科院分区：
文献类型：
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作者：
Dong, Xiang;Cao, Yi-yuan;Gao, Ya-dong
背景及目的由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）感染引起的2019冠状病毒病（COVID-19）爆发最近在全球蔓延，并被宣布为大流行。我们的目的是在这里描述的各种临床表现，这种疾病的检查11例。方法收集11例COVID-19患者的电子病历，讨论人口统计学、临床表现、结局、关键实验室检查结果和放射学影像。结果11例病例的临床过程显示了COVID-19特征的复杂性，具有不同的临床表现。临床表现从无症状病例到症状轻重不等的患者，可伴或不伴肺炎。病毒核酸的实验室检测可能产生假阴性结果，病毒特异性IgG和IgM抗体的血清学检测应作为诊断的替代方法。常见过敏性疾病患者症状不明显，病程不重。有慢性阻塞性肺疾病或并发继发性细菌性肺炎的病例更严重。结论应考虑COVID-19的所有不同临床特征，以确定需要严格隔离的患者，以有效遏制大流行。
Background and aims The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has recently spread worldwide and been declared a pandemic. We aim to describe here the various clinical presentations of this disease by examining eleven cases. Methods Electronic medical records of 11 patients with COVID-19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed. Results The clinical course of the eleven cases demonstrated the complexity of the COVID-19 profile with different clinical presentations. Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Laboratory detection of the viral nucleic acid can yield false-negative results, and serological testing of virus-specific IgG and IgM antibodies should be used as an alternative for diagnosis. Patients with common allergic diseases did not develop distinct symptoms and severe courses. Cases with a pre-existing condition of chronic obstructive pulmonary disease or complicated with a secondary bacterial pneumonia were more severe. Conclusion All different clinical characteristics of COVID-19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic.