Pendant allyl crosslinking as a tunable shape memory actuator for vascular applications.
Pendant allyl crosslinking as a tunable shape memory actuator for vascular applications.
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DOI：
10.1016/j.actbio.2015.06.004
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发表时间：
2015-09
影响因子：
9.7
通讯作者：
Sung HJ
中科院分区：
文献类型：
--
作者：
Boire TC;Gupta MK;Zachman AL;Lee SH;Balikov DA;Kim K;Bellan LM;Sung HJ
热响应形状记忆聚合物（SMP）可以配合到小孔切口中，并且在体内部署后恢复其功能形状。这种特性对于开发下一代微创医疗设备具有重要意义。为了用于这样的应用，SMP应该表现出足够的机械强度，以最大限度地减少不良顺应性失配诱导的宿主反应（例如血栓形成、增生），是可生物降解的，并且在接近体温时表现出开关状形状恢复，具有良好的生物相容性。组合方法在优化SMP材料的特定应用性能方面是必不可少的。在这项研究中，一类新的热响应性SMP与侧，光交联烯丙基，x%聚（-己内酯）-co-y %（-烯丙基羧酸酯-己内酯）（x%PCL-y%ACPCL），创建了一个强大的，容易的方式与容易调节的材料性能。热机械和形状记忆性能可以通过烯丙基组合物的细微变化而急剧改变。分子量和凝胶含量也可以在这种组合形式中改变，以微调材料特性。材料在37 °C附近表现出高弹性、开关状形状恢复。内皮相容性与组织培养聚苯乙烯（TCPS）和100%PCL在体外相当，血管相容性在后肢缺血的小鼠模型中在体内得到证实，表明血管应用的前景。
Thermo-responsive shape memory polymers (SMPs) can be fit into small-bore incisions and recover their functional shape upon deployment in the body. This property is of significant interest for developing the next generation of minimally-invasive medical devices. To be used in such applications, SMPs should exhibit adequate mechanical strengths that minimize adverse compliance mismatch-induced host responses (e.g. thrombosis, hyperplasia), be biodegradable, and demonstrate switch-like shape recovery near body temperature with favorable biocompatibility. Combinatorial approaches are essential in optimizing SMP material properties for a particular application. In this study, a new class of thermo-responsive SMPs with pendant, photocrosslinkable allyl groups, x%poly( -caprolactone)-co-y%( -allyl carboxylate -caprolactone) (x%PCL-y%ACPCL), are created in a robust, facile manner with readily tunable material properties. Thermomechanical and shape memory properties can be drastically altered through subtle changes in allyl composition. Molecular weight and gel content can also be altered in this combinatorial format to fine-tune material properties. Materials exhibit high elastic, switch-like shape recovery near 37 °C. Endothelial compatibility is comparable to tissue culture polystyrene (TCPS) and 100%PCL in vitro and vascular compatibility is demonstrated in vivo in a murine model of hindlimb ischemia, indicating promising suitability for vascular applications.