Characterization and biodegradation of chitosan-alginate polyelectrolyte complexes
Characterization and biodegradation of chitosan-alginate polyelectrolyte complexes
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DOI：
10.1016/j.polymdegradstab.2008.10.017
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发表时间：
2009-01-01
影响因子：
5.9
通讯作者：
Ma, Xiaojun
中科院分区：
文献类型：
--
作者：
Li, Xiaoxia;Xie, Hongguo;Ma, Xiaojun
聚电解质复合物（佩奇）由于其广泛的应用而成为研究的热点。本研究探讨了壳聚糖-藻酸盐佩奇的特性和生物降解性，通过冷冻干燥沉淀物从两种聚合物的充分混合物制备。X射线光电子能谱（XPS）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）和差示扫描量热（DSC）分析表明，壳聚糖的部分质子化胺基与海藻酸钠的羧酸基团发生了反应，形成了较强的佩奇。在溶菌酶溶液中孵育后，由于壳聚糖与海藻酸钠之间的强烈相互作用以及紧密吸附的溶菌酶的阻碍作用，尽管壳聚糖的脱乙酰度不同，佩奇仍表现出较高的酶吸附能力，但降解率较低。(C)2008爱思唯尔有限公司保留所有权利。
Polyelectrolyte complexes (PECs) have been the focus of an expanding number of studies for their wide use. This study investigated the characteristics and biodegradation of chitosan-alginate PECs prepared by freeze-drying a precipitate from sufficient mixtures of the two polymers. The analyses of X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC) suggested that the partial protonated amine groups of chitosan reacted with the carboxylate groups of alginate and thus strong PECs were formed. After incubating in lysozyme solution, the PECs showed high ability of enzyme adsorption, and low degradation rate in spite of different degrees of deacetylation of chitosan, due to the strong interaction between chitosan and alginate and the hindrance of closely adsorbed lysozyme. (C) 2008 Elsevier Ltd. All rights reserved.