Acute migraine medication adherence, migraine disability and patient satisfaction: A naturalistic daily diary study.
Acute migraine medication adherence, migraine disability and patient satisfaction: A naturalistic daily diary study.
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急性偏头痛药物依从性、偏头痛残疾和患者满意度：一项自然主义每日日记研究。
DOI：
10.1177/0333102416663459
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Nicholson RA
中科院分区：
文献类型：
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作者：
Seng EK;Robbins MS;Nicholson RA
研究急性偏头痛药物依从性对偏头痛残疾和急性药物满意度的影响。患有偏头痛的成年人完成了三个月的每日电子日记，评估头痛症状、服用的急性药物、急性药物满意度和每日偏头痛残疾。重复测量混合效应模型检查了初始药物类型[偏头痛专用药物 (MSM) 与非处方镇痛药 (OTC) 与阿片/巴比妥]、给药时疼痛严重程度的影响，以及它们对日常偏头痛残疾和急性药物满意度的相互作用。参与者（N = 337；92.5% 为女性，91.1% 为白人，非西班牙裔，84.0% 患有阵发性偏头痛）记录了 29,722 天的日记。在 8,090 个偏头痛日中，96.5% 的参与者服用了急性药物。 MSM 的服用频率最高 (58.0%)，其次是 OTC (29.9%) 和阿片/巴比妥 (12.1%)。轻度疼痛时最常服用急性药物（41.2%），其次是中度疼痛（37.7%）和重度疼痛（11.4%）。最初在疼痛较轻时服用 MSM 与最低的日常残疾 [药物 X 给药时疼痛 F(4, 6336.12) = 58.73, p < .001] 和最高的急性药物满意度 [药物 X 给药时疼痛 F(4, 3867.36) = 24.00, p < .001] 相关。首先使用 MSM（曲普坦或麦角）与最低的偏头痛残疾和最高的急性药物满意度相关。
To examine the influence of acute migraine medication adherence on migraine disability and acute medication satisfaction. Adults with migraine completed three months of daily electronic diaries assessing headache symptoms, acute medication taken, acute medication satisfaction, and daily migraine disability. Repeated measures mixed effects models examined the effect of initial medication type [migraine-specific medication (MSM) vs. over-the-counter analgesic (OTC) vs. Opiate/Barbiturate], pain severity at dosing, and their interaction on daily migraine disability and acute medication satisfaction. Participants (N = 337; 92.5% female, 91.1% Caucasian, Non-Hispanic, 84.0% with episodic migraine) recorded 29,722 diary days. Participants took acute medication on 96.5% of 8,090 migraine days. MSM was taken first most frequently (58.0%), followed by OTC (29.9%) and Opiate/Barbiturate (12.1%). Acute medication was most frequently taken when pain was mild(41.2%), followed by moderate (37.7% ) and severe (11.4%). Initially dosing with MSM while pain was mild was associated with the lowest daily disability [Medication X Pain at Dosing F(4, 6336.12) = 58.73, p < .001] and highest acute medication satisfaction [Medication X Pain at Dosing F(4, 3867.36) = 24.00, p < .001]. Using an MSM (triptan or ergot) first was associated with lowest migraine disability and highest acute medication satisfaction.