Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate
Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate
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DOI：
10.1016/j.vaccine.2007.03.031
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发表时间：
2007-05-30
期刊：
影响因子：
5.5
通讯作者：
Pijoan, Carlos
中科院分区：
文献类型：
--
作者：
Cano, Jean Paul;Dee, Scott A.;Pijoan, Carlos
本研究的目的是评价用改良的猪繁殖与呼吸综合征病毒（PRRSV）活疫苗进行治疗性疫苗干预对猪群中异源病毒感染动力学的影响，并确定先前暴露并接种疫苗的猪对第二次强毒异源攻毒的临床和病毒学应答。用田间分离株PRRSV MN-30100单独感染320头猪的群体，或在感染后1周开始以30天间隔施用Ingelvac PRRS MLV疫苗1 - 3次。疫苗干预减少了病毒脱落的持续时间，但没有减少组织中的病毒载量或持续感染猪的比例。然后在首次暴露后97天，给予不同的高毒力田间分离株MN-184作为异源病毒攻击。先前感染和接种疫苗的猪在用PRRSV MN-184高毒力攻击后显示出临床体征显著减少和增重增加，但不能防止攻击分离株的感染和脱落。(C)2007爱思唯尔有限公司版权所有。
The objectives of this study were to evaluate the effects of a therapeutic vaccine intervention with a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine on the dynamics of a heterologous viral infection in a population of pigs, and to determine the clinical and virological response of previously exposed and vaccinated pigs against a second virulent heterologous challenge. A population of 320 pigs were infected with a field isolate, PRRSV MN-30100, alone or followed by Ingelvac((R)) PRRS MLV vaccine administered one to three times at 30 days intervals beginning I week after infection. Vaccine intervention reduced the duration of viral shedding, but did not reduce the viral load in tissues or the proportion of persistently infected pigs. A different and highly virulent field isolate, MN-184, was then given as a heterologous viral challenge at 97 days after first exposure. Previously infected and vaccinated pigs showed a significant reduction in clinical signs and enhanced weight gain after the highly virulent challenge with PRRSV MN-184, but infection with and shedding of the challenge isolate were not prevented. (C) 2007 Elsevier Ltd. All rights reserved.