Acute fatty liver of pregnancy in a Chinese Tertiary Care Center: a retrospective study
Acute fatty liver of pregnancy in a Chinese Tertiary Care Center: a retrospective study
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中国三级医疗中心妊娠期急性脂肪肝的回顾性研究
DOI：
10.1007/s00404-019-05259-w
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发表时间：
2019-10-01
影响因子：
2.6
通讯作者：
Zhao, Xianlan
中科院分区：
文献类型：
--
作者：
Chen, Gezi;Huang, Kai;Zhao, Xianlan
目的探讨AFLP的产前临床特点和实验室检查结果，为临床医生预测产后恢复时间提供依据.方法回顾性分析郑州大学第一附属医院收治的44例AFLP患者的临床资料.结果治疗后母儿死亡率均为18.2%，其中14例为新生儿; AFLP的主要症状为恶心、呕吐（63.6%）、黄疸（61.4%）。最常见的母体并发症为急性肾功能不全（79.5%），其次为DIC（47.7%）和MODS（38.6%）。血小板、总蛋白、总胆红素水平与产后恢复时间相关（Pearson相关系数分别为0.434，P = 0.008; 0.466，P = 0.005; 0.484，P = 0.003）。一旦高度怀疑AFLP，应立即终止妊娠。产前血小板、总蛋白和总胆红素可能是产后恢复的潜在预测因素。
PurposeTo describe some prenatal clinical features and laboratory findings of AFLP and provide the clinicians with potential predictors in postpartum recovery time.MethodsForty-four cases of AFLP previously treated in the First Affiliated Hospital of Zhengzhou University were retrospectively reviewed.ResultsThe maternal and fetal mortalities after treatment were both 18.2%. The main symptoms of AFLP were nausea and vomiting (63.6%), jaundice (61.4%). Moreover, the most common maternal complication was acute renal dysfunction (79.5%), followed by DIC (47.7%) and MODS (38.6%). The level of platelets, total protein and total bilirubin were found to be correlated with postpartum recovery time (Pearson correlation coefficient 0.434,P= 0.008; 0.466,P= 0.005; 0.484,P= 0.003).ConclusionsAFLP is a rare, but lethal complication in the third trimester. Termination of pregnancy should be applied once AFLP was highly suspected. Prenatal platelets, total protein and total bilirubin may be potential predictors of postpartum recovery.