Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM).
Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM).
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DOI：
10.1007/978-1-0716-1811-0_23
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发表时间：
2022
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无损离子操作结构（SLIM）是行波离子迁移谱（TW-IMS）的一个强大变体，它使用沉积在印刷电路板上的蛇形微电极图案来实现超长离子路径长度（13.5 m）。离子通过TW电极阵列被推进通过SLIM平台，而RF和DC电极提供径向约束，建立近乎无损的传输。最近通过SLIM多次循环离子的能力已经允许离子路径长度超过1000 m，提供了前所未有的分离能力和观察离子结构构象的能力，这是其他IMS技术无法获得的。高分离能力、高信号强度以及与质谱法耦合的能力的组合使SLIM处于能够通过允许表征含有低丰度分析物的异构体混合物来解决长期存在的蛋白质组学和代谢组学挑战的独特位置。
Structures for Lossless Ion Manipulations (SLIM) is a powerful variant of traveling wave ion mobility spectrometry (TW-IMS) that uses a serpentine pattern of microelectrodes deposited onto printed circuit boards to achieve ultralong ion path lengths (13.5 m). Ions are propelled through SLIM platforms via arrays of TW electrodes while RF and DC electrodes provide radial confinement, establishing near lossless transmission. The recent ability to cycle ions multiple times through a SLIM has allowed ion path lengths to exceed 1000 m, providing unprecedented separation power and the ability to observe ion structural conformations unobtainable with other IMS technologies. The combination of high separation power, high signal intensity, and the ability to couple with mass spectrometry places SLIM in the unique position of being able to address longstanding proteomics and metabolomics challenges by allowing the characterization of isomeric mixtures containing low abundance analytes.