Repressing the Keratinocyte Genome: How the Polycomb Complex Subunits Operate in Concert to Control Skin and Hair Follicle Development.
Repressing the Keratinocyte Genome: How the Polycomb Complex Subunits Operate in Concert to Control Skin and Hair Follicle Development.
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抑制角质形成细胞基因组：Polycomb复合体子单元如何共同运行以控制皮肤和毛囊发育。
DOI：
10.1016/j.jid.2016.04.026
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Mardaryev AN
中科院分区：
文献类型：
--
作者：
Botchkarev VA;Mardaryev AN
Polycomb组蛋白是转录抑制因子，在干细胞分化为特化细胞类型的过程中，对于控制干细胞活性和维持细胞特性至关重要。多梳蛋白相互作用形成两种类型的染色质相关抑制复合体(多梳抑制复合体1和2，Prc1/2)，导致染色质紧凑和基因沉默。然而，PRC2复合体的不同成分在控制皮肤发育和角质形成细胞分化中的作用仍然不清楚。在本期中，Dauber等人。研究表明，有条件地去除表皮前体细胞中聚梳抑制复合体2的三个基本亚基(EED、Suz12或Ezh1/2)会导致非常相似的皮肤表型，包括过早获得功能性表皮屏障，异位Merkel细胞的形成，以及出生后毛囊发育缺陷。这些数据表明，在皮肤上皮细胞中，EED、Suz12和Ezh1/2主要作为PRC2复合体的亚单位发挥作用，这在证明它们在其他细胞类型或癌细胞中独立活动的数据背景下是重要的。Dauber等人的数据。为进一步分析提供了一个重要的平台，以充分了解Polycomb基因在控制表皮发育和再生中抑制作用的复杂性，并为分析不同的Polycomb成分在控制角质形成细胞基因表达程序变化中的作用开辟了新的途径，在银屑病等表皮分化障碍或表皮癌症中。
The Polycomb group proteins are transcriptional repressors that are critically important for the control of stem cell activity and the maintenance of cellular identity during stem cell differentiation into specialized cell types. Polycomb proteins interact with each other to form chromatin-associated repressive complexes of two general types (Polycomb Repressive Complexes 1 and 2, PRC1/2) leading to chromatin compaction and gene silencing. However, the roles of the distinct components of the PRC2 complex in the control of skin development and keratinocyte differentiation remain obscure. In this issue, Dauber et al. demonstrate that conditional ablations of three essential subunits of the Polycomb Repressive Complex 2 (EED, Suz12, or Ezh1/2) in the epidermal progenitor result in very similar skin phenotypes including the premature acquisition of a functional epidermal barrier, formation of ectopic Merkel cells, and defective postnatal hair follicle development. These data demonstrate that in the skin epithelium, EED, Suz12, and Ezh1/2 function largely as subunits of the PRC2 complex, which is important in the context of the data demonstrating the possibility for their independent activities in other cell types or in cancer cells. The data of Dauber et al. provide an important platform for further analyses to fully understand the complexity of repressive action of the Polycomb genes in the control of epidermal development and regeneration, as well as open new avenue for analyses of the role of distinct Polycomb components in the control of alterations of the gene expression programs in keratinocytes in the disorders of epidermal differentiation, such as psoriasis, or in epidermal cancers.
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影响因子：
10.5
作者：
Ezhkova, Elena;Lien, Wen-Hui;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
7.7
作者：
Zhang T;Cooper S;Brockdorff N
通讯作者：
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影响因子：
64.5
作者：
Ezhkova E;Pasolli HA;Parker JS;Stokes N;Su IH;Hannon G;Tarakhovsky A;Fuchs E
通讯作者：
Fuchs E
DOI：
10.1038/jid.2010.318
发表时间：
2011-02
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
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影响因子：
11.4
作者：
Bardot, Evan S.;Valdes, Victor J.;Ezhkova, Elena
通讯作者：
Ezhkova, Elena