Pacemaker Mechanisms in Myocardial Cells during Development of Embryonic Chick Hearts
Pacemaker Mechanisms in Myocardial Cells during Development of Embryonic Chick Hearts
复制标题
鸡胚心脏发育过程中心肌细胞的起搏机制
DOI：
10.1007/978-94-009-7535-4_8
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
N. Sperelakis
中科院分区：
文献类型：
--
作者：
N. Sperelakis
在胚胎发育期间，心脏发生重要变化，包括超微结构、代谢、药理学和电生理学变化。例如，鸡胚心脏发育过程中，心室肌细胞的电特性发生了显著的变化。这些电生理学变化包括细胞自动性和起搏能力的变化。每个发育阶段的电特性决定了该阶段心脏的许多功能特性。对胚胎心脏细胞电生理特性的研究不仅有助于阐明分化过程中的变化，而且可以为理解成人心脏复杂的电生理学提供线索。同样，培养的心脏细胞可能被证明是有用的模型系统，在其中研究心脏细胞的自律性。
Important changes occur in the heart during embryonic development, including ultrastructural, metabolic, pharmacological, and electrophysiological changes. For example, striking changes occur in the electrical properties of ventricular myocardial cells during embryonic development of chick heart. These electrophysiological changes include changes in automaticity and pacemaker capabilities of the cells. The electrical properties at each stage of development determine many of the functional properties of the heart at that stage. Studies on the electrophysiological properties of embryonic heart cells are useful, not only for elucidating the changes during differentiation, but also may provide clues for understanding the complex electrophysiology of adult hearts. Similarly, cultured heart cells may prove useful as a model system in which to study automaticity of heart cells.