Recent advances in the diagnosis and treatment of hypereosinophilic syndromes.
Recent advances in the diagnosis and treatment of hypereosinophilic syndromes.
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DOI：
10.1182/asheducation-2005.1.209
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
A. Klion
中科院分区：
文献类型：
--
作者：
A. Klion
高嗜酸性粒细胞综合征(HES)是一组异质性疾病，其特征是明显的外周血液和组织嗜酸性粒细胞增多，导致终末器官损害。分子生物学和免疫学的最新进展导致了一些不同亚型的HES的鉴定，这些亚型具有不同的流行病学、发病机制和预后。区分这些HES亚型的能力，加上新的治疗方式的可用性，包括酪氨酸激酶抑制剂和单抗，靶向参与疾病发病机制的特定分子，极大地改变了HES的诊断和治疗方法。
Hypereosinophilic syndromes (HES) are a heterogeneous group of disorders characterized by marked peripheral blood and tissue eosinophilia resulting in end organ damage. Recent advances in molecular biology and immunology have led to the identification of a number of distinct subtypes of HES with differing epidemiology, pathogenesis, and prognosis. The ability to distinguish between these HES subtypes combined with the availability of new treatment modalities, including tyrosine kinase inhibitors and monoclonal antibodies, that target specific molecules involved in disease pathogenesis have dramatically altered the approach to the diagnosis and treatment of HES.