Trypanosoma cruzi:: infection patterns in intact and athymic mice of susceptible and resistant genotypes
Trypanosoma cruzi:: infection patterns in intact and athymic mice of susceptible and resistant genotypes
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DOI：
10.14670/hh-17.837
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发表时间：
2002-07-01
影响因子：
2
通讯作者：
Lagrange, PH
中科院分区：
文献类型：
--
作者：
da Costa, SCG;Calabrese, KS;Lagrange, PH
就寄生虫血症的程度和死亡率而言，接种T cruzi Y品系的小鼠近交品系表现出易感（A/J、C3H/HeN）、中间（BALB/c）或相对抗性（C57BL/6）。 C57BL/10 小鼠对寄生虫血症敏感，但在分析死亡率时具有抵抗力。用克氏锥虫 CL 株感染也呈现出相同的结果，但 C57BL/6 除外，其表现为易感小鼠。不同背景的无胸腺小鼠显示出易感性没有差异，表现出相同的显着寄生虫血症、组织定植模式，并且在任何研究的组织中都没有炎症反应。感染正常和无胸腺的 BALB/c 小鼠会产生寄生虫特异性抗体，这些抗体在前 9 天达到相似的水平，但在第 13 天后有所不同。BALB/c 小鼠的血清转移实验没有显示出寄生虫血症的巨大差异，但改变了克氏锥虫多态性，减少了无胸腺小鼠的细长形式。无胸腺 BALB/c 小鼠在感染 T cruzi Y 或 CL 菌株时显示出相同的组织向性。
Inbred strains of mice inoculated with the T cruzi Y strain behaved as susceptible (A/J, C3H/HeN), intermediate (BALB/c) or relatively resistant (C57BL/6) with respect to the magnitude of parasitaemia and mortality rate. C57BL/10 mice were susceptible in relation to parasitaemia but resistant when mortality was analyzed. Infection with T cruzi CL strain presented the same results, except for C57BL/6 which behaved as susceptible mice. Athymic mice of various backgrounds revealed no differences in susceptibility, presenting the same dramatic parasitaemia, tissue colonization pattern and no inflammatory reaction in any of the tissues studied. Infection of euthymic and athymic BALB/c mice elicited the production of parasite-specific antibodies, which reached similar levels on the first 9 days but differed after day 13. Serum transfer experiments in BALB/c mice did not show great differences in parasitaemia but altered T. cruzi polymorphism reducing the slender forms in athymic mice. Histopathology of athymic BALB/c mice showed the same tissue tropism when infected either with T cruzi Y or CL strain.