Association of polyomavirus middle tumor antigen with 14-3-3 proteins.
Association of polyomavirus middle tumor antigen with 14-3-3 proteins.
复制标题
多瘤病毒中间肿瘤抗原与 14-3-3 蛋白的关联。
DOI：
10.1126/science.8036498
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Roberts,TM
中科院分区：
文献类型：
--
作者：
Pallas,DC;Fu,H;Haehnel,LC;Weller,W;Collier,RJ;Roberts,TM
为了实现其转化功能，鼠多瘤病毒的中间肿瘤抗原（MT）与参与调节细胞增殖的许多细胞蛋白质缔合，包括pp 60 c-Src、磷脂酰肌醇3-激酶、蛋白磷酸酶2A、Src同源蛋白和胶原蛋白以及生长因子受体结合蛋白2。在此，另外两种MT相关蛋白被鉴定为14-3-3蛋白家族的成员。酵母同源物14-3-3蛋白最近已被证明在有丝分裂的时间中发挥作用。因此，MT对14-3-3蛋白功能的调节可能有助于肿瘤的发展。
To carry out its transformation function, the middle tumor antigen (MT) of murine polyomavirus associates with a number of cellular proteins involved in regulation of cell proliferation, including pp60c-Src, phosphatidylinositol 3-kinase, protein phosphatase 2A, Src homologous and collagen protein and growth factor receptor-binding protein 2. Here, two additional MT-associated proteins were identified as members of the 14-3-3 family of proteins. Yeast homologs of 14-3-3 proteins have recently been shown to play a role in the timing of mitosis. Thus, regulation of 14-3-3 protein function by MT may contribute to the development of neoplasia.
DOI：
10.1073/pnas.90.6.2320
发表时间：
1993-03-15
影响因子：
11.1
作者：
FU, H;COBURN, J;COLLIER, RJ
通讯作者：
COLLIER, RJ