Models for synthetic biology
Models for synthetic biology
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DOI：
10.1186/1752-0509-1-47
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发表时间：
2007-11-06
影响因子：
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通讯作者：
Kaznessis, Yiannis N.
中科院分区：
文献类型：
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作者：
Kaznessis, Yiannis N.
合成生物工程从生物学中浮现为基于定量的独特学科。这些技术推动合成生物学并不是什么新鲜事物，设计新型生物分子的概念也不是什么。新的重点是系统行为。目标是设计和构建新的生物设备和系统以提供有用的应用程序。在过去的十年中，已经创建了许多合成基因回路，包括Bissable开关，振荡器和逻辑大门，并且可能的应用比比皆是，包括生物燃料，生化和化学武器的检测器，疾病诊断和基因疗法越多。发现DNA的分子结构，分子生物学已经足够成熟，足以实现对生物工程应用有用的实际定量1950年代化学建模的革命。兴奋地说，合成生物学正在产生，工程和生物科学社区似乎非常愿意跨越纪律界面，以实现一个共同的目标。
Synthetic biological engineering is emerging from biology as a distinct discipline based on quantification. The technologies propelling synthetic biology are not new, nor is the concept of designing novel biological molecules. What is new is the emphasis on system behavior.The objective is the design and construction of new biological devices and systems to deliver useful applications. Numerous synthetic gene circuits have been created in the past decade, including bistable switches, oscillators, and logic gates, and possible applications abound, including biofuels, detectors for biochemical and chemical weapons, disease diagnosis, and gene therapies.More than fifty years after the discovery of the molecular structure of DNA, molecular biology is mature enough for real quantification that is useful for biological engineering applications, similar to the revolution in modeling in chemistry in the 1950s. With the excitement that synthetic biology is generating, the engineering and biological science communities appear remarkably willing to cross disciplinary boundaries toward a common goal.