Annexins: Ca2+ Effectors Determining Membrane Trafficking in the Late Endocytic Compartment
Annexins: Ca2+ Effectors Determining Membrane Trafficking in the Late Endocytic Compartment
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DOI：
10.1007/978-3-319-55858-5_14
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Grewal, Thomas
中科院分区：
文献类型：
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作者：
Enrich, Carlos;Rentero, Carles;Grewal, Thomas
尽管40年前就发现了膜联蛋白，但我们才刚刚开始了解这些仍然神秘的蛋白质的一些功能。通过其以Ca2+依赖性方式结合阴离子膜脂质的能力来定义和表征，每个膜联蛋白都被认为是多功能蛋白质，具有众多的细胞位置和不同的活性。这种相当大的功能多样性的根本原因包括它们与多种胞质和膜蛋白相关联的能力。近年来，越来越多地认识到建立亚细胞区室之间的膜接触位点打开了一个新的情况下，膜联蛋白作为工具球员连接Ca2+信号与膜贩运在细胞生理学的许多方面的整合。在这一章中，我们回顾和讨论目前的知识的贡献膜联蛋白的生物起源和功能的后期内吞隔室，影响各种生理后果，从膜修复，溶酶体胞吐，细胞迁移的内分泌和胞吐途径。
Despite the discovery of annexins 40 years ago, we are just beginning to understand some of the functions of these still enigmatic proteins. Defined and characterized by their ability to bind anionic membrane lipids in a Ca2+-dependent manner, each annexin has to be considered a multifunctional protein, with a multitude of cellular locations and diverse activities. Underlying causes for this considerable functional diversity include their capability to associate with multiple cytosolic and membrane proteins. In recent years, the increasingly recognized establishment of membrane contact sites between subcellular compartments opens a new scenario for annexins as instrumental players to link Ca2+ signalling with the integration of membrane trafficking in many facets of cell physiology. In this chapter, we review and discuss current knowledge on the contribution of annexins in the biogenesis and functioning of the late endocytic compartment, affecting endo- and exocytic pathways in a variety of physiological consequences ranging from membrane repair, lysosomal exocytosis, to cell migration.