Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
复制标题
Neurexin-1 是果蝇突触形成和幼虫联想学习所必需的
DOI：
10.1016/j.febslet.2007.04.068
复制
发表时间：
2007-05-29
期刊：
影响因子：
3.5
通讯作者：
Xie, Wei
中科院分区：
文献类型：
--
作者：
Zeng, Xiankun;Sun, Mingkuan;Xie, Wei
神经毒素是神经元中高度多态的细胞表面粘附分子。在培养的哺乳动物细胞系统中，发现它们参与突触发生。在这里，我们报告的第一次，果蝇neurexin需要突触形成和联想学习幼虫。果蝇基因组编码一种单一功能性neurexin（CG 7050; Neurexin-1或Nurexin-1），其是脊椎动物α-neurexin的同系物。Neurexin-1在中枢神经系统中表达，并且在腹神经节和脑的突触区域中高度富集。Neurexin-1无效突变体是可行的和可育的，但具有缩短的寿命。在Neurexin-1无效突变体中，中枢神经系统中的突触数量减少。此外，Neurexin-1无效突变体在幼虫中表现出联想学习缺陷。(c)2007年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Neurexins are highly polymorphic cell-surface adhesive molecules in neurons. In cultured mammalian cell system, they were found to be involved in synaptogenesis. Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae. Drosophila genome encodes a single functional neurexin (CG7050; Neurexin-1 or Nrx-1), which is a homolog of vertebrate a-neurexin. Neurexin-1 is expressed in central nervous system and highly enriched in synaptic regions of the ventral ganglion and brain. Neurexin-1 null mutants are viable and fertile, but have shortened lifespan. The synapse number is decreased in central nervous system in Neurexin-1 null mutants. In addition, Neurexin-1 null mutants exhibit associative learning defect in larvae. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.