Resting-state functional connectivity of the medial superior frontal cortex.
Resting-state functional connectivity of the medial superior frontal cortex.
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DOI：
10.1093/cercor/bhr088
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Shenmin Zhang;J. Ide;C. Li
中科院分区：
文献类型：
--
作者：
Shenmin Zhang;J. Ide;C. Li
内侧上级额叶皮层（SFC），包括辅助运动区（SMA）和前辅助运动区（presupplementary motor area，preSMA），涉及运动和认知控制，以及其他决策中枢功能。先前的研究描绘了SMA的解剖学边界和功能连接。然而，目前还不清楚是否preSMA，响应各种行为任务，包括功能不同的领域。与24个种子区域系统划定整个前，后内侧SFC，我们在这里检查的基础上的“相关图”的休息状态功能磁共振成像数据的225个成年人的内侧SFC的功能部门。除了复制隔离的SMA和后前SMA，目前的结果阐明了功能连接的前前SMA的最前部的内侧SFC。相反，尾侧内侧SFC，前SMA与大部分的前额叶，但不与somatomotor地区。总的来说，SMA与丘脑和上丘脑紧密相连，SMA后前体与壳核、苍白球和丘脑底核紧密相连，SMA前体与尾状核紧密相连，尾状核表现出明显的半球不对称性。这些发现可能为未来研究额叶皮质功能提供一个有用的平台。
The medial superior frontal cortex (SFC), including the supplementary motor area (SMA) and presupplementary motor area (preSMA), is implicated in movement and cognitive control, among other functions central to decision making. Previous studies delineated the anatomical boundaries and functional connectivity of the SMA. However, it is unclear whether the preSMA, which responds to a variety of behavioral tasks, comprises functionally distinct areas. With 24 seed regions systematically demarcated throughout the anterior and posterior medial SFC, we examined here the functional divisions of the medial SFC on the basis of the "correlograms" of resting-state functional magnetic resonance imaging data of 225 adult individuals. In addition to replicating segregation of the SMA and posterior preSMA, the current results elucidated functional connectivities of anterior preSMA-the most anterior part of the medial SFC. In contrast to the caudal medial SFC, the anterior preSMA is connected with most of the prefrontal but not with somatomotor areas. Overall, the SMA is strongly connected to the thalamus and epithalamus, the posterior preSMA to putamen, pallidum, and subthalamic nucleus, and anterior preSMA to the caudate, with the caudate showing significant hemispheric asymmetry. These findings may provide a useful platform for future studies to investigate frontal cortical functions.