CD4+ T cell response in early erythrocytic stage malaria: Plasmodium berghei infection in BALB/c and C57BL/6 mice
CD4+ T cell response in early erythrocytic stage malaria: Plasmodium berghei infection in BALB/c and C57BL/6 mice
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DOI：
10.1007/s00436-009-1435-8
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发表时间：
2009-07-01
影响因子：
2
通讯作者：
Watanabe, Junichi
中科院分区：
文献类型：
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作者：
Shibui, Akiko;Hozumi, Nobumichi;Watanabe, Junichi
伯氏疟原虫ANKA在小鼠中引起致命的疟疾。C57BL/6小鼠早死，伴有惊厥等暴发性症状，而BALB/c小鼠在这一阶段存活，晚死于贫血和虚弱。C57BL/6小鼠的早期死亡被认为是由炎症细胞因子的不良作用引起的。为了阐明CD4(+) T细胞在严重疟疾早期死亡中的反应，通过分析细胞表面标记物和细胞因子和转录因子的产生，比较了CD4(+) T细胞的动力学。结果显示，CD4(+) T细胞早在感染后5天就能诱导细胞因子的产生，维持较高水平的IL-4和IL-10可能与BALB/c小鼠免于早期死亡的保护有关。这些结果表明，在感染的早期阶段控制寄生虫可能对开发有效的疫苗很重要。
Plasmodium berghei ANKA causes lethal malaria in mice. It is well established that C57BL/6 mice die early with fulminant symptoms including convulsion, whereas BALB/c mice survive this phase and die later of anemia and prostration. Early death in C57BL/6 mice has been considered to result from the adverse effects of inflammatory cytokines. To elucidate the CD4(+) T cell responses in early death due to severe malaria, the kinetics of CD4(+) T cells were compared by analyzing cell surface markers and the production of cytokines and transcription factors. The results revealed that cytokine production by CD4(+) T cells was induced as early as 5 days after infection and the maintenance of higher levels of IL-4 and IL-10 may be associated with the protection of BALB/c mice from early death. These results suggest that parasite control in the early phase of infection may be important for the development of an effective vaccine.