The gut microbiome in autoimmunity: Sex matters.
The gut microbiome in autoimmunity: Sex matters.
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DOI：
10.1016/j.clim.2015.04.016
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Taneja V
中科院分区：
文献类型：
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作者：
Gomez A;Luckey D;Taneja V
类风湿性关节炎等自身免疫性疾病本质上是多因素的，需要遗传和环境因素才能发病。女性易患各种自身免疫性疾病的倾向增加，表明这些疾病的多因素病因学存在性别偏见。然而，现有的证据迄今为止还没有提供任何结论性的机制，性别偏见的作用以外的激素和性染色体。肠道微生物组影响免疫的先天和适应性分支，不仅影响自身免疫性疾病的发展，而且可能与性激素相互作用以调节疾病进展和性别偏见。在这里，我们回顾了目前关于自身免疫中性别偏见的信息，并讨论了微生物组来源的生物标志物的潜力，以帮助解开类风湿性关节炎中基因，环境和激素之间复杂的相互作用。
Autoimmune diseases like rheumatoid arthritis are multifactorial in nature, requiring both genetic and environmental factors for onset. Increased predisposition of females to a wide range of autoimmune diseases points to a gender bias in the multifactorial etiology of these disorders. However, the existing evidence tol date has not provided any conclusive mechanism of gender- bias beyond the role of hormones and sex chromosomes. The gut microbiome, which impacts the innate and adaptive branches of immunity, not only influences the development of autoimmune disorders but may interact with sex-hormones to modulate disease progression and sex-bias. Here, we review the current information on gender bias in autoimmunity and discuss the potential of microbiome-derived biomarkers to help unravel the complex interplay between genes, environment and hormones in rheumatoid arthritis.