Impaired restitution of blood volume after large hemorrhage.
Impaired restitution of blood volume after large hemorrhage.
复制标题
大出血后血容量恢复受损。
DOI：
10.1097/00005373-198108000-00002
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Allen-Rowlands,CF
中科院分区：
文献类型：
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作者：
Gann,DS;Carlson,DE;Byrnes,GJ;PirkleJr,JC;Allen-Rowlands,CF
先前的研究表明，细胞外渗透压的增加介导了10%出血后细胞内液向小肠的转移。这种单向流体运动是血容量（BV）完全恢复和心血管稳定所需的。这些研究检查了这种机制在较大出血中的作用程度。42只狗在脾切除术后3周进行了研究。其中20人被戊巴比妥麻醉，其他人在清醒状态下进行研究。在3分钟内进行10%（7.5 ml/kg，15只犬）、20%（15 ml/kg，13只犬）和30%（22.5 ml/kg，15只犬）的出血。
Previous studies have suggested that increases in extracellular osmolality mediate a shift of intracellular fluid into the interstitium following 10% hemorrhage. This unidirectional fluid movement is required for full restitution of blood volume (BV) and for cardiovascular stabilization. The extent to which this mechanism acts in larger hemorrhages was examined in these studies. Forty-two dogs were studied 3 weeks after splenectomy. Twenty were anesthetized with pentobarbital, the others were studied awake. Hemorrhages of 10%(7.5 ml/kg, 15 dogs), 20%(15 ml/kg, 13 dogs), and 30%(22.5 ml/kg, 15 dogs) were carried out over 3 minutes.