Mortality rates in patients with Barrett's oesophagus
Mortality rates in patients with Barrett's oesophagus
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DOI：
10.1111/j.1365-2036.2007.03582.x
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发表时间：
2008-02-15
影响因子：
7.6
通讯作者：
Jankowski, J.
中科院分区：
文献类型：
--
作者：
Moayyedi, P.;Burch, N.;Jankowski, J.
背景Barrett食管患者发生食管腺癌的风险增加。观察性研究也表明总体死亡率增加，但数据相互矛盾。目的评估巴雷特食管患者与普通人群相比的死亡原因。方法使用电子内窥镜和组织病理学记录，在英国莱斯特郡的四家医院回顾性识别巴雷特食管患者1997年至2003年。从这个队列的患者死亡的数据，确定通过国家统计局和年龄和性别调整后的死亡率在莱斯特郡region.ResultsIn所有，1272巴雷特的患者被确定为245例死亡，在这个队列。发现总体死亡率增加[男性标准化死亡率比（SMR）= 552，95% CI = 466-638;女性SMR 455，95% CI = 357-552]。造成这一增加的主要疾病领域是食管腺癌（n = 25，男性SMR = 2171，95% CI = 991-3351;女性SMR = 1300，95% CI = 26-2574），支气管扩张症（n = 70，男性SMR = 146，95% CI = 55-236;女性SMR = 436，95% CI = 272-601）和缺血性心脏病（n = 51，男性SMR = 186，95% CI = 97-2748;女性SMR = 205，95% CI = 105-306）.结论Barrett食管患者死于支气管扩张症和缺血性心脏病的比例高于食管腺癌，总死亡率可能增加。
BackgroundPatients with Barrett's oesophagus are at increased risk of oesophageal adenocarcinoma. Observational studies have suggested increase in overall mortality also but data are conflicting.AimTo assess the cause of death in patients with Barrett's oesophagus compared with the general population.MethodsPatients with Barrett's oesophagus were identified retrospectively in four hospitals in Leicestershire, UK using electronic endoscopy and histopathology records from 1997 to 2003. Data on deaths from this cohort of patients were identified through the Office of National Statistics and compared with age- and gender-adjusted mortality in the Leicestershire region.ResultsIn all, 1272 Barrett's patients were identified with 245 deaths in this cohort. Overall mortality was found to be increased [male standardized mortality ratio (SMR) = 552, 95% CI = 466-638; female SMR 455, 95% CI = 357-552]. The main disease areas that were responsible for this increase were oesophageal adenocarcinoma (n = 25, male SMR = 2171, 95% CI = 991-3351; female SMR = 1300, 95% CI = 26-2574), bronchopneumonia (n = 70, male SMR = 146, 95% CI = 55-236; female SMR = 436, 95% CI = 272-601) and ischaemic heart disease (n = 51, male SMR = 186, 95% CI = 97-2748; female SMR = 205, 95% CI = 105-306).ConclusionsPatients with Barrett's oesophagus die more commonly of bronchopneumonia and ischaemic heart disease compared with oesophageal adenocarcinoma, and overall mortality in this group may be increased.