Mechanisms of obesity-associated cardiovascular and renal disease
Mechanisms of obesity-associated cardiovascular and renal disease
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DOI：
10.1097/00000441-200209000-00003
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发表时间：
2002-09-01
影响因子：
3.1
通讯作者：
Dubbert, PM
中科院分区：
文献类型：
--
作者：
Hall, JE;Crook, ED;Dubbert, PM
肥胖是美国最常见的营养失调症。越来越多的证据表明，肥胖引发了一系列疾病，包括高血压、糖尿病、动脉粥样硬化和慢性肾脏疾病，其中许多疾病是相互依赖的。由肾小管重吸收增加引起的肾功能异常在体重过度增加期间引发体积膨胀和血压升高，并且与肥胖相关的高血压和代谢异常反过来促成慢性肾脏疾病。肥胖通过众所周知的介质如高血压、II型糖尿病和血脂异常引起心脏和血管疾病，但有证据表明存在不太明确的介质，如慢性炎症和高凝状态。虽然肥胖越来越被认为是一个严重的健康问题，但关于与体重过度增加相关的多种疾病如何相互作用导致心血管和肾脏疾病，仍然有许多未回答的问题。此外，很少有研究检查肥胖受试者的持续减肥是否可以逆转这些变化。鉴于我国肥胖的“流行病”以及少数人群心血管和肾脏疾病的过度负担，解决这些问题对于杰克逊心脏研究以及其他国家健康计划至关重要。
Obesity is the most common nutritional disorder in the United States. Growing evidence suggests that obesity initiates a cascade of disorders including hypertension, diabetes, atherosclerosis, and chronic renal disease, many of which are interdependent. Abnormal kidney function, caused by increased renal tubular reabsorption, initiates volume expansion and increased blood pressure during excess weight gain, and the hypertension and metabolic abnormalities associated with obesity, in turn, contribute to chronic renal disease. Obesity causes cardiac and vascular disease through well-known mediators such as hypertension, type II diabetes, and dyslipidemia, but there is evidence for less well-characterized mediators such as chronic inflammation and hypercoagulation. Although obesity is increasingly recognized as a serious health problem, there are still many unanswered questions about how the multiple disorders associated with excess weight gain interact to cause cardiovascular and renal disease. Also, there are few studies that have examined whether sustained weight loss in obese subjects can reverse these changes. In view of the "epidemic" of obesity in our country and the excess burden of cardiovascular and renal disease in minority populations, addressing these issues is of paramount importance for the Jackson Heart Study, as well as for other national health initiatives.