Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging.
Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging.
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DOI：
10.1089/ham.2011.1073
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发表时间：
2012-06
影响因子：
2.1
通讯作者：
Haiyan Zhang;Jianzhong Lin;Yingchun Sun;Yongxia Huang;Huiming Ye;Xiaochuan Wang;Tianhe Yang;
中科院分区：
文献类型：
--
作者：
Haiyan Zhang;Jianzhong Lin;Yingchun Sun;Yongxia Huang;Huiming Ye;Xiaochuan Wang;Tianhe Yang;
本研究的目的是调查单次短期登山后大脑微结构的变化。对14名登山者在登山（6206 m）前后进行了灰质（GM）和白质（WM）体积的基于体素的形态测量（VBM）分析以及基于MRI图像的WM分数各向异性（FA）的基于束的空间统计（TBSS）分析。此外，还测试了言语和空间“双背”任务以及串行反应时间任务。登山后GM、WM和脑脊液总量和局部体积均未检测到显着变化。双侧皮质脊髓束、胼胝体（前体和后体、压部）、背侧中脑网状结构、左上纵束、右后扣带束和左小脑中脚的 FA 值显着降低。在上述所有区域中，径向扩散率值均呈增加趋势，但左上纵束的变化具有统计学显着性。登山后两项认知测试均无明显变化。这些发现表明，短期高海拔暴露主要导致大脑 WM 紊乱，显示纤维微结构完整性受损，这可能阐明了先前测试的一些认知和运动缺陷的机制。
The aim of the present study was to investigate cerebral microstructural alterations after single short-term mountain climbing. Voxel-based morphometry (VBM) analysis of gray matter (GM) and white matter (WM) volumes and Tract-Based Spatial Statistics (TBSS) analysis of WM fractional anisotropy (FA) based on MRI images were carried out on 14 mountaineers before and after mountain climbing (6206 m). In addition, verbal and spatial 'two-back' tasks and serial reaction time task were also tested. No significant changes were detected in total and regional volumes of GM, WM, and cerebral spinal fluid after mountain climbing. Significant decreased FA values were found in the bilateral corticospinal tract, corpus callosum (anterior and posterior body, splenium), reticular formation of dorsal midbrain, left superior longitudinal fasciculus, right posterior cingulum bundles, and left middle cerebellar peduncle. In all the above regions, the radial diffusivity values tended to increase, except in the left superior longitudinal fasciculus the change was statistically significant. There were no significant changes in the two cognitive tests after mountain climbing. These findings indicate that short-term high-altitude exposure leads to disturbances mainly in cerebral WM, showing compromised fiber microstructural integrity, which may clarify the mechanisms underlining some cognitive and motor deficits tested previously.