Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2.
Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2.
复制标题
2A 型多发性内分泌肿瘤基因定位于染色体带 10q11.2 的 480 kb 区域。
DOI：
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发表时间：
1993
影响因子：
3.5
通讯作者：
A. Tunnacliffe
中科院分区：
文献类型：
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作者：
S. Mole;L. Mulligan;C. Healey;B. Ponder;A. Tunnacliffe
在人类染色体10q11.2带上构建了一个横跨1.1 Mb的YAC序列，其中包含三个与MEN 2A基因密切相关的标记（D10S141、RET、D10S94）。这个物理连锁组的序列为cen-D10S141-RET-D10S94-qter，必须包含MEN2A，它位于两侧标记D10S141和D10S94之间的480 kb区域。
A YAC contig has been constructed spanning 1.1 Mb of human chromosome band 10q11.2 which encompasses three markers (D10S141, RET, D10S94) closely linked to the gene for MEN 2A. This physical linkage group is ordered cen-D10S141-RET-D10S94-qter, and must include MEN2A, which lies in a 480 kb region between flanking markers D10S141 and D10S94.