Iodine-123-BMIPP myocardial washout and cardiac work during exercise in normal and ischemic hearts.
Iodine-123-BMIPP myocardial washout and cardiac work during exercise in normal and ischemic hearts.
复制标题
Iodine-123-BMIPP 正常心脏和缺血心脏运动期间的心肌冲洗和心脏做功。
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
T. Nakagawa
中科院分区：
文献类型：
--
作者：
K. Takeda;K. Saito;K. Makino;Y. Saito;S. Aoki;T. Koji;K. Matsumura;Y. Nomura;T. Kitano;T. Nakagawa
未标记
研究了静息和运动后碘-123-BMIPP洗脱与正常和缺血心肌心脏作功的关系。
方法
对16名健康志愿者和10名缺血性心脏病患者进行了检查。注射123 I-BMIPP 111 MBq后，连续SPECT显像，以评估静息和轻度及最大运动后的洗脱率（WR）。
结果
在健康志愿者中，休息1小时后的平均WR为3.3 +/- 3.5%，在轻度和最大运动期间均增加。WR与净压力速率乘积（PRP）的相关性优于与峰值PRP的相关性。在最大运动量后，WR在200-300 x 10（3）mmHg/min范围内与净PRP显示出明显的相关性，然后显示出大于10%的平台。在5名净PRP ≥ 300 x 10（3）mmHg/min的缺血性心脏病患者中，相对于缺血节段，正常节段的运动WR值显著升高。
结论
在正常心肌中，BMIPP洗脱随运动期间心脏作功的增加而增加，但在缺血心肌中不增加。一定量的运动对评价正常和缺血心肌的脂肪酸代谢是必要的。
UNLABELLED
Iodine-123-BMIPP washout at rest and after exercise was investigated in relation to cardiac work in normal and ischemic myocardium.
METHODS
Sixteen healthy volunteers and 10 patients with ischemic heart disease were examined. After injection of 111 MBq of 123I-BMIPP, successive SPECT imaging was performed to evaluate washout ratio (WR) at rest and after mild and maximal exercise.
RESULTS
In the healthy volunteers, the mean WR was 3.3 +/- 3.5% after 1 hr of rest and increased during both mild and maximal exercise. The WR showed a better correlation with net pressure rate product (PRP) than with the peak PRP. After maximal exercise, the WR showed a distinct correlation with the net PRP in the range from 200-300 x 10(3) mmHg/min and then showed a plateau greater than 10%. In five ischemic heart disease patients with the net PRP > or = 300 x 10(3) mmHg/min, the exercise WR values were significantly elevated in normal segments relative to ischemic segments.
CONCLUSION
BMIPP washout increased with the increase in cardiac work during exercise in normal myocardium but not in ischemic myocardium. A certain amount of exercise is necessary to evaluate fatty acid metabolism in normal and ischemic myocardium.