Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006.
Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006.
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DOI：
10.3201/eid1710.110087
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发表时间：
2011-10
影响因子：
11.8
通讯作者：
Kontoyiannis DP
中科院分区：
文献类型：
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作者：
Park BJ;Pappas PG;Wannemuehler KA;Alexander BD;Anaissie EJ;Andes DR;Baddley JW;Brown JM;Brumble LM;Freifeld AG;Hadley S;Herwaldt L;Ito JI;Kauffman CA;Lyon GM;Marr KA;Morrison VA;Papanicolaou G;Patterson TF;Perl TM;Schuster MG;Walker R;Wingard JR;Walsh TJ;Kontoyiannis DP
最近的报告描述了造血细胞移植（HCT）和实体器官移植（SOT）受者中非曲霉菌感染的发生率不断增加。调查毛霉目、镰刀菌属和Scedosporium spp.感染的流行病学。霉菌，我们分析了移植相关感染监测网络的数据，该网络有 23 个移植中心，这些中心在 2001 年至 2006 年期间对侵袭性真菌感染进行了前瞻性监测。我们在 169 名患者中发现了 169 种感染（105 种毛霉目、37 种镰刀菌属和 27 种Scedosporium spp.）； 124 例 (73.4%) 为 HCT 接受者，45 例 (26.6%) 为 SOT 接受者。 90天粗死亡率为56.6%。 HCT 的 12 个月毛霉菌病累积发病率为 0.29%，SOT 的 12 个月累积发病率为 0.07%。 HCT 受者的毛霉菌病发病率差异很大，从 0.08% 到 0.69%，其中 2003 年和 2004 年期间接受移植的人群的发病率较高。非曲霉菌感染仍然与高死亡率相关。在监测期间，HCT 接受者的毛霉菌病发病率大幅增加。
Recent reports describe increasing incidence of non-Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001–2006. We identified 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.