Biologically-Inspired Microphysiological Systems
Biologically-Inspired Microphysiological Systems
复制标题
DOI：
10.1016/b978-0-12-813697-3.00030-5
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Shuler, Michael
中科院分区：
文献类型：
--
作者：
Dehne, Eva-Maria;Hickman, James;Shuler, Michael
微生理学多器官器械旨在通过成功模仿生物体功能和对物质的反应来模拟各种互连器官模型的生理相互作用。体外多器官系统的第一个概念是在20世纪80年代末提出的，表明这种系统可以提供毒理学问题的机制见解。2010年，欧洲和美国的政府赠款和倡议大大加速了微生理系统的发展。研究这些设备的实验室和衍生公司数量的迅速增加，以及大型制药和化妆品公司的承诺，导致了各种应用系统的多样化。与监管科学驱动的努力相结合，从这些设备中获得的高质量数据为后来的认证研究奠定了基础。包括更多器官和功能的进一步进步导致了芯片上的系统性微生物，即所谓的芯片上的身体设备。这些系统最终将建立一个全新的物质检测范式。
Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances. The first concepts of in vitro multi-organ systems were put forward in the late 1980s, demonstrating that such systems could provide mechanistic insight into toxicology questions. In 2010, governmental grants and initiatives in Europe and the United States strongly accelerated the development of microphysiological systems. The rapid increase in the number of laboratories and spin-off companies working on these devices, and the commitment of big pharma and cosmetics companies, has led to the generation of a diversity of systems for various applications. In conjunction with regulatory science-driven efforts, high-quality data derived from these devices laid the foundation for later qualification studies. Further advancements to include more organs and functionalities lead the way toward systemic micro-organisms on a chip e so-called body-on-achip devices. These systems will eventually establish a completely new substance testing paradigm.