Phylogenetic profiles: A graphical method for detecting genetic recombinations in homologous sequences
Phylogenetic profiles: A graphical method for detecting genetic recombinations in homologous sequences
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DOI：
10.1093/oxfordjournals.molbev.a025929
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发表时间：
1998-03-01
影响因子：
10.7
通讯作者：
Weiller, GF
中科院分区：
文献类型：
--
作者：
Weiller, GF
系统发育剖面构成了一种新的方式，以图形方式显示序列关系在一组对齐的同源序列的整个长度上的一致性。使用滑动窗口技术，该方法确定窗口中所有序列的成对距离，并评估每个序列在这些区域的距离模式的一致程度。该方法适用于研究数据一致性和检测重组序列。本文开发了实现该算法的计算机程序，并给出了模拟序列和自然序列的实例，以证明该方法在识别重组序列及其重组连接以及检测重组活性热点方面的灵敏度和准确性。
Phylogenetic profiles constitute a novel way of graphically displaying the coherence of the sequence relationships over the entire length of a set of aligned homologous sequences. Using a sliding-window technique, this method determines the pairwise distances of all sequences in the windows and evaluates, for each sequence, the degree to which the patterns of distances in these regions agree. This method is suited for exploring data consistency as well as detecting recombinant sequences. A computer program implementing the algorithm has been developed, and examples with simulated and natural sequences are given to demonstrate the sensitivity and accuracy of the method for identifying recombinant sequences and their recombination junctions as well as detecting hot spots of recombinational activity.