External beam radiotherapy to treat intra- and extra-hepatic dissemination of hepatocellular carcinoma after radiofrequency thermal ablation
External beam radiotherapy to treat intra- and extra-hepatic dissemination of hepatocellular carcinoma after radiofrequency thermal ablation
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DOI：
10.1111/j.1440-1746.2006.04432.x
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发表时间：
2006-10-01
影响因子：
4.1
通讯作者：
Ohtomo, Kuni
中科院分区：
文献类型：
--
作者：
Yamashita, Hideomi;Nakagawa, Keiichi;Ohtomo, Kuni
射频消融（RFA）是经皮无水乙醇注射治疗（PEIT）的一种替代方法，用于治疗单发非手术肝细胞癌。然而，已经报道了沿针道沿着种植的风险。7例RFA或PEIT后出现肿瘤种植的患者使用常规分割进行外射束放疗。所有患者接受的总剂量范围为44-61戈伊（中位数和众数：50戈伊），7例患者中有6例（86%）达到了治疗的客观反应。2例患者（29%）获得完全缓解。中位生存时间为14.7个月，1年和2年生存率分别为67%和50%，治疗效果较好，无严重并发症。肝细胞癌的种植对外照射敏感。50戈伊分25次治疗是有效的。
Radiofrequency ablation (RFA) is an alternative to percutaneous ethanol injection therapy (PEIT) for single non-surgical hepatocellular carcinoma. However, the risk of seeding along the needle track has been reported.Seven patients presenting with neoplastic seeding after RFA or PEIT were treated with external beam radiotherapy using conventional fractionation. All patients underwent irradiation with a total dose in the range of 44-61 Gy (median and mode value: 50 Gy).An objective response to treatment was achieved in six of seven patients (86%). A complete response was obtained in two patients (29%). The median survival time was 14.7 months and the actuarial 1- and 2-year survivals were 67% and 50%, respectively.The response to treatment was relatively good without serious complications. Seeding from hepatocellular carcinoma is sensitive to external beam radiotherapy. It is useful in the treatment of these patients with 50 Gy in 25 fractions.