Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging - The multiethnic study of atherosclerosis
Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging - The multiethnic study of atherosclerosis
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DOI：
10.1016/j.jacc.2006.03.072
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发表时间：
2006-12-05
影响因子：
24
通讯作者：
Bluemke, David A.
中科院分区：
文献类型：
--
作者：
Heckbert, Susan R.;Post, Wendy;Bluemke, David A.
本研究的目的是在多种族动脉粥样硬化研究（梅萨）中检查心血管危险因素与通过心脏磁共振成像（MRI）测量的左心室（LV）几何形状和收缩功能的横断面相关性。背景已知心血管危险因素包括高血压、吸烟和肥胖与左心室质量增加相关，但对危险因素与左心室收缩功能的相关性知之甚少，特别是在无临床心血管疾病的人群中。参与者来自4个种族/民族，无临床心血管疾病。评估血压、健康习惯、体重指数、血脂水平和血糖异常，并在基线时进行MRI检查（n = 4，869）。采用多变量线性回归模型分析危险因素与左室质量、舒张末期容积、每搏输出量、射血分数和心输出量的相关性。结果平均年龄为62岁，52%的参与者为女性。调整社会人口统计学变量和身高后，较高的收缩压和体重指数与较大的LV质量和体积相关。目前吸烟和糖尿病与较大的左室质量相关（分别为+7.7 g，95%置信区间[CI] +5.5至+9.9和+3.5 g，95% CI +1.2至+5.8），且每搏输出量较低（分别为-1.9 ml，95% CI-3.3至-0.5和-4.5 ml，95% CI -6.0至-3.0）和射血分数较低（分别为-1.6%，95% CI-2.1至-1.0和-0.8%，95% CI -1.5至-0.2）。结论：在这个无临床心血管疾病的队列中，可改变的危险因素与心脏MRI检测到的LV大小和收缩功能的亚临床改变相关。
OBJECTIVES The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA). BACKGROUND Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease. METHODS Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output. RESULTS The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and + 3.5 g, 95% CI + 1.2 to + 5.8, respectively), and with lower stroke volume (- 1.9 ml, 95% Cl -3.3 to -0.5 and -4.5 ml, 95% CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6%, 95% Cl -2.1 to -1.0 and -0.8%, 95% CI -1.5 to -0.2, respectively). CONCLUSIONS In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.