The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older women
The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older women
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DOI：
10.1016/j.jad.2010.06.004
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发表时间：
2010-12-01
影响因子：
6.6
通讯作者：
Costa, Paul T., Jr.
中科院分区：
文献类型：
--
作者：
Sutin, Angelina R.;Beason-Held, Lori L.;Costa, Paul T., Jr.
背景：老年心境障碍增加了个人发病率和死亡率的风险，也增加了社会的医疗保健成本。特质神经质是导致这种疾病进入老年的一个强有力的风险因素，与抑郁症有着共同的遗传变异，但介导这种联系的更近端的生物学机制还没有得到很好的理解。此外，神经质的神经相关性的性别差异是否反映了行为测量的性别差异尚不清楚。本研究确定了与神经质相关的稳定神经活动的性别差异，并测试了这种活动是否前瞻性地介导了神经质和随后的抑郁症状。（46名女性）老年参与者（>55岁）进行了两次静息态PET扫描，间隔约两年，并完成了两次神经质和抑郁症状的测量。在这两个时间点重复，神经质与女性海马和中脑以及男性颞中回的静息状态局部脑血流活动呈正相关。对于女性，海马活动介导了基线神经质和随访时抑郁症状之间的关联。反向mediational model was not significant.Conclusions：神经质与稳定的神经活动的区域牵连在情绪处理和调节的女性，但不是男性。在女性中，神经质通过右侧海马体的更大活动前瞻性地预测抑郁症状，这表明神经质和女性抑郁之间存在一种神经机制。确定神经质和精神疾病之间的关联的负责机制可能有助于指导对这些疾病的药物干预研究。(C)出版社：Elsevier B.V.
Background: Mood disorders in old age increase the risk of morbidity and mortality for individuals and healthcare costs for society. Trait Neuroticism, a strong risk factor for such disorders into old age, shares common genetic variance with depression, but the more proximal biological mechanisms that mediate this connection are not well understood. Further, whether sex differences in the neural correlates of Neuroticism mirror sex differences in behavioral measures is unknown. The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms.Methods: A total of 100 (46 female) older participants (>55 years) underwent a resting-state PET scan twice, approximately two years apart, and completed measures of Neuroticism and depressive symptoms twice.Results: Replicating at both time points, Neuroticism correlated positively with resting-state regional cerebral blood-flow activity in the hippocampus and midbrain in women and the middle temporal gyrus in men. For women, hippocampal activity mediated the association between Neuroticism at baseline and depressive symptoms at follow-up. The reverse mediational model was not significant.Conclusions: Neuroticism was associated with stable neural activity in regions implicated in emotional processing and regulation for women but not men. Among women, Neuroticism prospectively predicted depressive symptoms through greater activity in the right hippocampus, suggesting one neural mechanism between Neuroticism and depression for women. Identifying responsible mechanisms for the association between Neuroticism and psychiatric disorders may help guide research on pharmacological interventions for such disorders across the lifespan. (C) 2010 Published by Elsevier B.V.