Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes
Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes
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DOI：
10.1016/j.bbrc.2010.01.134
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发表时间：
2010-03-12
影响因子：
3.1
通讯作者：
Shimomura, Iichiro
中科院分区：
文献类型：
--
作者：
Kozawa, Junji;Okita, Kohei;Shimomura, Iichiro
2型糖尿病患者的胰岛素分泌和对胰岛素分泌的影响尚未完全了解。我们研究了日本肥胖和非肥胖2型糖尿病患者与非糖尿病受试者餐后肠促胰岛素和胰岛素分泌。本研究招募了9名2型糖尿病患者和5名非糖尿病受试者。5名糖尿病患者为肥胖（BMI >= 25），4名患者为非肥胖（BMI < 25）。在混合餐试验中，非肥胖患者在15-90 min期间的免疫反应性胰岛素和0-180 min期间的C肽水平显著低于肥胖患者。总GLP-1和活性GIP水平在整个膳食耐受试验中显示肥胖和非肥胖患者之间无显著差异。此外，糖尿病患者和非糖尿病受试者之间无显著差异。总之，肠促胰岛素分泌在日本肥胖和非肥胖2型糖尿病患者与非糖尿病受试者之间没有差异。(C)2010年爱思唯尔公司All rights reserved.
secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI >= 25) and 4 patients were non-obese (BMI < 25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects. (C) 2010 Elsevier Inc. All rights reserved.