Cognitive Impairment Among Elderly Individuals in Shanghai Suburb, China: Association of C-Reactive Protein and its Interactions With Other Relevant Factors
Cognitive Impairment Among Elderly Individuals in Shanghai Suburb, China: Association of C-Reactive Protein and its Interactions With Other Relevant Factors
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中国上海郊区老年人认知障碍：C反应蛋白的关联及其与其他相关因素的相互作用。
DOI：
10.1177/1533317514534758
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发表时间：
2014-12-01
影响因子：
3.4
通讯作者：
Cheng, Qi
中科院分区：
文献类型：
--
作者：
Chen, Jin-Mei;Cui, Guo-Hong;Cheng, Qi
目的：为探讨血清C反应蛋白（CRP）浓度与认知功能损害的关系以及CRP与其他相关因素的交互作用，采用分层随机抽样的方法，选取上海市郊区60岁及以上的老年人为研究对象，随机分为认知功能损害组和1 ~ 2个年龄、性别匹配的对照组。结果：认知功能障碍组血清CRP水平明显高于对照组（P <0.001）; CRP最高四分位数（>4.77 mg/L）、腹部肥胖、高血糖症和高血糖症与认知功能障碍相关。CRP升高与高血糖、高甘油三酯血症在认知功能损害中存在显著的交互作用，交互作用的归因比例为82%（P <0.0001）和37%（P = .007）。结论：CRP升高与认知障碍有关，CRP升高与高血糖、高甘油三酯血症对老年人认知功能损害有相加作用。
Objectives: To investigate the association between serum C-reactive protein (CRP) concentration and cognitive impairment as well as interactions between CRP and other relevant factors.Methods: Patients with cognitive impairment and 1 to 2 age- and sex-matched controls nested from a population-based study among residents aged 60 years and older in Shanghai suburb. The associations of serum CRP concentration and other relevant factors were examined with logistic regression analysis.Results: The mean CRP in patients with cognitive impairment was higher than that in controls (P < .001). The highest quartile of CRP (>4.77 mg/L), abdomen obesity, hypertriglyceridemia, and hyperglycemia was associated with cognitive impairment. Significant interactions were found between increased CRP and hypertriglyceridemia as well as between increased CRP and hyperglycemia on cognitive impairment; and the attributable proportion due to interaction was 82% (P < .0001) and 37% (P = .007), respectively.Conclusions: Increased CRP was associated with cognitive impairment, and additive effects of increased CRP with hypertriglyceridemia and hyperglycemia on cognitive impairment were observed among elderly individuals.