Interleukin-1β-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia
Interleukin-1β-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia
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DOI：
10.1152/ajpregu.1998.274.6.r1829
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发表时间：
1998-06-01
影响因子：
2.8
通讯作者：
Kelley, KW
中科院分区：
文献类型：
--
作者：
Burgess, W;Gheusi, G;Kelley, KW
白细胞介素-1 β (IL-1 β)介导感染和炎症的许多行为反应，IL-1 β转化酶（ICE）处理细胞内IL-1 β，导致其成熟和分泌。在这里，我们证明了与ICE- /-缺乏小鼠相比，野生型小鼠脑室内注射脂多糖（LPS）可以更大程度地减少食物摄入量和食物动机行为。尽管ICE -/-小鼠能够对脑室内注射IL-1 β完全有反应，但仍发生了这种缺陷。相比之下，ICE -/-小鼠对腹腔注射LPS保持完全反应。这些结果表明，在炎症期间发生的食物摄入抑制中，大脑（而非外周）IL-1 β起着关键作用。
Interleukin-1 beta (IL-1 beta) mediates many of the behavioral responses to infection and inflammation, and IL-1 beta-converting enzyme (ICE) processes intracellular IL-1 beta, leading to its maturation and secretion. Here we demonstrate that intracerebroventricular injections of lipopolysaccharide (LPS) produced a greater reduction in both food intake and food-motivated behavior in wild-type compared with ICE-deficient (ICE -/-) mice. This defect occurred although ICE -/- mice were able to fully respond to intracerebroventricular injections of IL-1 beta. In contrast, ICE -/- mice remained fully responsive to intraperitoneal injections of LPS. These results indicate that brain, but not peripheral, IL-1 beta plays a critical role in the depression in food intake that occurs during inflammation.