Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.
Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.
复制标题
对吞噬功能遗传异常患者的白细胞代谢活性进行研究。
DOI：
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发表时间：
1967
影响因子：
15.9
通讯作者：
R. Good
中科院分区：
文献类型：
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作者：
B. Holmes;A. Page;R. Good
来自慢性肉芽肿病患者的多形性白细胞对乳胶颗粒的吞噬作用的反应是葡萄糖消耗、乳酸产生、克雷布斯循环活性和脂质周转的正常增加。这些患者的白细胞在呼吸、葡萄糖的直接氧化和颗粒摄取过程中的过氧化氢形成中不能显示正常的增量。似乎呼吸刺激与过氧化氢的形成和葡萄糖代谢的直接氧化途径的刺激与多形核白细胞对细菌的脱粒和细胞内杀伤密切相关。
Polymorphonuclear leukocytes from patients with chronic granulomatous disease respond to the phagocytosis of latex particles with normal increments in glucose consumption, lactate production, Krebs' cycle activity, and lipid turnover. The leukocytes of these patients fail to show normal increments in respiration, direct oxidation of glucose, and hydrogen peroxide formation during particle uptake. It appears that the stimulation of respiration with the formation of hydrogen peroxide and stimulation of the direct oxidative pathway of glucose metabolism are closely linked to degranulation and intracellular killing of bacteria by polymorphonuclear leukocytes.