Effects of Different Levels of Food Restriction on Passive-Avoidance Memory and The Expression of Synapsin I in Young Mice
Effects of Different Levels of Food Restriction on Passive-Avoidance Memory and The Expression of Synapsin I in Young Mice
复制标题
DOI：
10.1080/00207450802328250
复制
发表时间：
2009-01-01
影响因子：
2.2
通讯作者：
Han, P. -Z.
中科院分区：
文献类型：
--
作者：
Deng, L.;Wu, Z. -N.;Han, P. -Z.
本研究观察了食物限制(FR)对幼年小鼠记忆和脑内突触素I表达的影响。结果表明，20%FR对小鼠体重增长无明显影响，而60%和80%FR对小鼠体重有明显的抑制作用。FR对学习24小时后的记忆无明显影响，而对20%FR小鼠的长时记忆有显著改善。此外，60%和80%的FR对小鼠的记忆没有影响。20%FR可上调小鼠脑内突触素I的转录表达，60%和80%FR可下调突触素I的转录表达。
The present study investigated the effects of food restriction (FR) on memory and the expression of synapsin I in the brain of young mice. The results showed that 20% FR did not retard the body weight gain of mice, while the 60% and 80% FR reduced the mice's body weight. The memory after 24 hr of learning was not changed by FR, whereas long-term memory was improved significantly in 20% FR mice. In addition, 60% and 80% FR did not impair the mice's memory. The transcriptional expression of synapsin I in mice brain was up-regulated by 20% FR, and down-regulated by 60% and 80% FR.