Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration.
Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration.
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DOI：
10.1513/pats.200705-063vs
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Hershenson, Marc B
中科院分区：
文献类型：
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作者：
Bentley, J Kelley;Hershenson, Marc B
气道平滑肌质量增加存在于致命性和非致命性哮喘中。然而，关于细胞机制（即，增生对肥大）。关于气道平滑肌重塑的功能后果的信息甚至更少。似乎增加气道平滑肌质量将倾向于增加气道狭窄和气流阻塞。然而，气道平滑肌质量增加对气道狭窄的确切影响尚不清楚。本综述将考虑哮喘气道平滑肌细胞增殖和肥大的证据，潜在的功能效应和生化机制。
Increased airway smooth muscle mass is present in fatal and non-fatal asthma. However, little information is available regarding the cellular mechanism (i.e., hyperplasia vs. hypertrophy). Even less information exists regarding the functional consequences of airway smooth muscle remodeling. It would appear that increased airway smooth muscle mass would tend to increase airway narrowing and airflow obstruction. However, the precise effects of increased airway smooth muscle mass on airway narrowing are not known. This review will consider the evidence for airway smooth muscle cell proliferation and hypertrophy in asthma, potential functional effects, and biochemical mechanisms.