Scaling of myocardial mass to flow and morphometry of coronary arteries
Scaling of myocardial mass to flow and morphometry of coronary arteries
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DOI：
10.1152/japplphysiol.01261.2007
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发表时间：
2008-05-01
影响因子：
3.3
通讯作者：
Kassab, Ghassan S.
中科院分区：
文献类型：
--
作者：
Choy, Jenny Susana;Kassab, Ghassan S.
心肌质量与冠状动脉血管形态计量学之间无疑存在比例关系。本研究的目的是量化与心肌质量相关的冠状动脉树的几个形态（直径、长度和体积）和功能（流量）参数。本研究中使用了8个117-244 g（平均177.5 +/- 32.7）的正常猪心脏。左前降支、右冠状动脉和左回旋支动脉的各种冠状动脉子树在100 mmHg的压力下用不同颜色的聚合物（Microfil）灌注，以获得对应于心肌质量的不同区域的动脉树的橡胶模型。冠状动脉的体积、直径和累积长度从铸型重建，以分析它们与灌注心肌质量的关系。测量了与灌注心肌质量相关的体积流量。我们的研究结果表明，动脉容积与局部心肌质量呈线性关系，而冠状动脉分支长度、血管直径和容积流量之和与心肌质量分别呈3/4、3/8和3/4幂律关系。这些标度律表明了冠状动脉树结构-功能关系的基本设计原则，可能有助于弥漫性冠状动脉疾病的诊断和管理。
There is no doubt that scaling relations exist between myocardial mass and morphometry of coronary vasculature. The purpose of this study is to quantify several morphological (diameter, length, and volume) and functional (flow) parameters of the coronary arterial tree in relation to myocardial mass. Eight normal porcine hearts of 117-244 g (mean of 177.5 +/- 32.7) were used in this study. Various coronary subtrees of the left anterior descending, right coronary, and left circumflex arteries were perfused at pressure of 100 mmHg with different colors of a polymer (Microfil) to obtain rubber casts of arterial trees corresponding to different regions of myocardial mass. Volume, diameter, and cumulative length of coronary arteries were reconstructed from casts to analyze their relationship to the perfused myocardial mass. Volumetric flow was measured in relationship with perfused myocardial mass. Our results show that arterial volume is linearly related to regional myocardial mass, whereas the sum of coronary arterial branch lengths, vessel diameters, and volumetric flow show an similar to 3/4, 3/8, and 3/4 power-law relationship, respectively, in relation to myocardial mass. These scaling laws suggest fundamental design principles underlying the structure-function relationship of the coronary arterial tree that may facilitate diagnosis and management of diffuse coronary artery disease.