Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: A PET and MR study
Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: A PET and MR study
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DOI：
10.1002/jmri.10021
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发表时间：
2001-12-01
影响因子：
4.4
通讯作者：
Powers, WJ
中科院分区：
文献类型：
--
作者：
Lin, W;Celik, A;Powers, WJ
虽然它已被证明，脑血流量（CBF）的定量措施，可以得到与奇异值分解（SVD）算法，在何种程度上可以利用定量CBF测量的病理生理条件下还没有得到系统的研究。共5名健康志愿者和5名单侧颈动脉闭塞患者进行了研究。仅采集志愿者组的磁共振（MR）图像，而采集患者组的MR和正电子发射断层扫描（PET）图像。正常志愿者的CBF评估与文献报道的值相比是有利的。然而，当MR测量的CBF与PET获得的CBF相比时，观察到每例患者的线性关系，当所有患者作为一个组进行分析时，这种线性关系减弱（r = 0.41）。提出了一个校正因子（CF），等于每例患者的静脉输出功能（VOF）面积与从志愿者组获得的平均VOF的比值。在根据实验得出的CF对每例患者的CBF进行全局缩放后，观察到AIR估计的CBF与PET获得的CBF之间的关系有实质性改善（线性回归线的斜率为1.02，r = 0.8）。(C)2001 Wiley-Liss，Inc.
Although it has been demonstrated that quantitative measures of cerebral blood flow (CBF) can be obtained with the singular value decomposition (SVD) algorithm, the extent to which quantitative CBF measurements can be utilized under pathophysiological conditions has not been systematically studied. A total of five healthy volunteers and five patients with unilateral carotid artery occlusion were studied. Only magnetic resonance (MR) images were acquired for the volunteer group while both MR and positron emission tomography (PET) Images were acquired for the patient group. Assessments of CBF from normal volunteers compared favorably with values reported in the literature. However, while a linear relationship was observed for each patient when MR measured CBF was compared to that obtained from PET, this linear relationship diminished when all patients were analyzed as a group (r = 0.41). A correction factor (CF) was proposed that was equal to the ratio of the area of the venous output function (VOF) in each patient to the mean VOF obtained from the volunteer group. After globally scaling the CBF of each patient based on the experimentally derived CF, a substantial improvement was observed (a slope of 1.02 and r = 0.8 for the linear regression line) in the relationship between AIR estimated CBF and those obtained from PET. (C) 2001 Wiley-Liss, Inc.