Retinal pathology in Alzheimer's disease .1. Ganglion cell loss in foveal/parafoveal retina
Retinal pathology in Alzheimer's disease .1. Ganglion cell loss in foveal/parafoveal retina
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DOI：
10.1016/0197-4580(96)00010-3
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发表时间：
1996-05-01
影响因子：
4.2
通讯作者：
Blanks, RHI
中科院分区：
文献类型：
--
作者：
Blanks, JC;Torigoe, Y;Blanks, RHI
对9例阿尔茨海默病(AD)患者和11例正常对照眼中央视网膜神经节细胞层(中心凹/中心凹/黄斑旁)神经元数量的形态计量学分析表明，AD组神经元总数较对照眼减少25%。对中心凹不同偏心处GCL神经元的详细分析表明，中央0~0.5 mm(中心凹)处神经元密度下降幅度最大(43%)，0.5~1 mm处和1~1.5 mm处分别为24%和26%。中央视网膜的颞区受到的影响最严重，中心凹附近的神经元密度下降了52%(中心偏心0-0.5 mm)。分别分析3例AD和3例对照病例的对侧眼睛之间有密切的一致性。对神经元大小的分析表明，所有大小的神经元在AD中都受到类似的影响。在对照视网膜的GCL中，神经元随着年龄的增长而减少(相关系数=-0.67)，而在AD视网膜中，这种关系并不明显。由于在视网膜中央0-2 mm区域，GCL内97%的神经元是神经节细胞(其余3%由移位的无长突细胞组成)，这些结果表明AD患者中央视网膜广泛的神经节细胞丢失。
Morphometric analysis of the numbers of neurons in the ganglion cell layer (GCL) of the central retina (fovea/foveola/parafoveal retina) in eyes from 9 Alzheimer's disease (AD) and 11 age-marched control cases revealed an overall decrease of 25% in total numbers of neurons in AD as compared with control eyes. Detailed analyses of GCL neurons at various eccentricities from the foveola showed that the greatest decrease in neuronal density (43% decrease) occurred in the central 0-0.5 mm (foveal region), while at 0.5-1 mm and at 1-1.5 mm eccentricities, neuronal loss amounted to 24 and 26%, respectively. The temporal region of the central retina appeared most severely affected, with up to 52% decrease in neuronal density near the foveola (central 0-0.5 mm eccentricity). There was close agreement between fellow eyes analyzed separately for three AD and three control cases. Analysis of neuronal sizes showed that all sizes of neurons were similarly affected in AD. In the GCL of control retinas, neurons decreased with age (coefficient of correlation = -0.67), while in AD retinas no such relationship was evident. Since in the central 0-2 mm region of the retina 97% of neurons in the GCL are ganglion cells (while the remaining 3% consist of displaced amacrine cells), these results demonstrate extensive ganglion cell loss in the central retina in AD.