Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection
Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection
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DOI：
10.1017/s0950268813003178
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发表时间：
2014-10-01
影响因子：
4.2
通讯作者：
Pichichero, M. E.
中科院分区：
文献类型：
--
作者：
Friedel, V.;Zilora, S.;Pichichero, M. E.
在7价肺炎球菌结合疫苗（PCV）时代（2006年7月至2011年6月）儿童鼻咽（NP）定植和急性中耳炎（AOM）感染的5年前瞻性研究中，我们研究了NP定植和AOM的危险因素。NP样本收集在年龄6，9，12，15，18，24和30个月期间，良好的儿童访问。此外，在每次AOM发作时收集NP和中耳液（MEF）样本。从1825次访视（n = 464名儿童）中，收集了5301份NP和570份MEF样本，并分析了潜在的耳病原体。日托出勤率、卡他莫拉菌NP定植和年龄
During a 5-year prospective study of nasopharyngeal (NP) colonization and acute otitis media (AOM) infections in children during the 7-valent pneumococcal conjugate vaccine (PCV) era (July 2006-June 2011) we studied risk factors for NP colonization and AOM. NP samples were collected at ages 6, 9, 12, 15, 18, 24, and 30 months during well-child visits. Additionally, NP and middle ear fluid (MEF) samples were collected at onset of every AOM episode. From 1825 visits (n = 464 children), 5301 NP and 570 MEF samples were collected and analysed for potential otopathogens. Daycare attendance, NP colonization by Moraxella catarrhalis, and siblings aged