Differential Sensitivity to the Effects of Psychotropic Drugs: Psychotics vs Normals; Asian vs Western Populations
Differential Sensitivity to the Effects of Psychotropic Drugs: Psychotics vs Normals; Asian vs Western Populations
复制标题
对精神药物作用的不同敏感性：精神病患者与正常人；
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
T. Ōkuma
中科院分区：
文献类型：
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作者：
T. Ōkuma
翻译后摘要：精神药物的影响和副作用是由许多变量决定的，和主机的因素是最重要的。精神分裂症患者对氯丙嗪的镇静作用的敏感性低于正常人，躁狂抑郁症患者对丙咪嗪的敏感性低于正常人，这一点通过用药后清醒EEG的百分比时间较高来定量证明。在一项比较卡马西平和氯丙嗪抗躁狂疗效的对照研究中，发现日本人中氯丙嗪治疗躁狂状态的平均治疗剂量远低于西方人群。据报道，亚洲人群中其他抗精神病药物、锂和三环类抗抑郁药的治疗剂量也较低。从跨文化精神药理学的角度讨论了较低的治疗剂量水平。
Abstract: The effects and side‐effects of psychotropic drugs are determined by many variables, and the host factor is one of the most important. A lower sensitivity of schizophrenics than normals to the sedative effect of chlorpro‐mazine and of manic depressives to imipramine were demonstrated quantitatively by a higher percent time of waking EEG following medication. The mean therapeutic dose of chlorpromazine for the manic state was found to be much lower in Japanese than in Western populations in a controlled study comparing the antimanic efficacy of carbamazepine and chlorpromazine. A lower therapeutic dose in Asian populations has been reported also on other antipsychotic drugs, lithium, and tricyclic antidepressants. The lower therapeutic dose level was discussed from the standpoint of transcultural psy‐chopharmacology.